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Management of pubertal and transitioning patients with growth hormone deficiency has also commanded increased attention. Recent clinical studies that demonstrate the positive health benefits of recombinant human growth hormone in children with cystic fibrosis, inflammatory bowel disease, and juvenile rheumatoid arthritis have not yet clarified issues about patient selection and appropriate long-term use. An understanding of current recombinant human growth hormone indications and controversies can facilitate patient evaluation and expedite referral for potential treatment. This review summarizes current indications for recombinant human growth hormone use, discusses clinical challenges, and provides recommendations for pediatricians caring for children who may be appropriate candidates for recombinant human growth hormone therapy.<\/jats:p>","DOI":"10.1177\/0009922806293924","type":"journal-article","created":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T19:50:29Z","timestamp":1179949829000},"page":"279-286","source":"Crossref","is-referenced-by-count":20,"title":["Twenty Years of Recombinant Human Growth Hormone in Children: Relevance to Pediatric Care Providers"],"prefix":"10.1177","volume":"46","author":[{"given":"Dana S.","family":"Hardin","sequence":"first","affiliation":[{"name":"Ohio State University and Columbus Children's Hospital, -state.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Kemp","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences at Arkansas Children's Hospital, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Allen","sequence":"additional","affiliation":[{"name":"University of Wisconsin Medical School, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,5,1]]},"reference":[{"key":"atypb1","unstructured":"Allen DB Growth hormone treatment. 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