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Experts have conceded that booster vaccination of adolescents may considerably decrease the incidence of pertussis infections in previously immunized, partially immunized, and nonimmunized populations. Studies in 2 tetanus, diphtheria, and acellular pertussis (Tdap) booster vaccines licensed by the Food and Drug Administration (FDA) have shown efficacy against pertussis disease and have demonstrated a safety profile comparable to tetanus and diphtheria vaccine (Td) in adolescents. Immunization schedules now include use of Tdap vaccines for preadolescent and adolescent populations to counter the increase in pertussis outbreaks. Challenges for clinicians include prompt recognition of pertussis symptoms, proper diagnosis using appropriate tools, and timely reporting of pertussis infections to surveillance bodies. Additional studies are needed to monitor trends of pertussis incidence after implementing the new vaccination schedule for adolescents.<\/jats:p>","DOI":"10.1177\/0009922806295276","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:21:41Z","timestamp":1182460901000},"page":"785-794","source":"Crossref","is-referenced-by-count":4,"title":["Rationale for Use of Tdap Booster Vaccines for Adolescent Immunization: Overview of Efficacy, Safety, and Clinical Use"],"prefix":"10.1177","volume":"45","author":[{"given":"William P.","family":"Hitchcock","sequence":"first","affiliation":[{"name":"La Jolla Pediatrics, La Jolla, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,11,1]]},"reference":[{"key":"atypb1","first-page":"75","volume-title":"Epidemiology and Prevention of Vaccine-Preventable Diseases","author":"Centers for Disease Control and Prevention","year":"2004","edition":"8"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1086\/515057"},{"key":"atypb3","first-page":"11","volume":"41","author":"Davis SF","year":"1992","journal-title":"MMWR"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1086\/514776"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.3.708"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199608000-00004"},{"key":"atypb7","first-page":"216","volume":"53","author":"Centers for Disease Control and Prevention","year":"2004","journal-title":"MMWR."},{"key":"atypb8","first-page":"822","volume":"46","author":"Centers for Disease Control and Prevention","year":"1997","journal-title":"MMWR."},{"key":"atypb9","first-page":"197","volume":"42","author":"Centers for Disease Control and Prevention","year":"1993","journal-title":"MMWR."},{"key":"atypb10","first-page":"2","volume":"33","author":"Centers for Disease Control and Prevention","year":"1984","journal-title":"MMWR."},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1086\/319853"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000160708.43944.99"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1086\/315863"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000145263.37198.2b"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1086\/315648"},{"key":"atypb16","volume-title":"First combination vaccine approved to help protect adolescents against whooping cough","author":"US Food and Drug Administration"},{"key":"atypb17","volume-title":"FDA approves a new combination vaccine to help protect both adolescents and adults against whooping cough","author":"US Food and Drug Administration"},{"key":"atypb18","volume-title":"Society for Adolescent Medicine","author":"D\u2019Angelo LJ"},{"key":"atypb19","first-page":"1","volume":"52","author":"Centers for Disease Control and Prevention","year":"2005","journal-title":"MMWR."},{"key":"atypb20","first-page":"1213","volume":"53","author":"Centers for Disease Control and Prevention","year":"2005","journal-title":"MMWR."},{"key":"atypb21","first-page":"770","volume":"54","author":"Centers for Disease Control and Prevention","year":"2005","journal-title":"MMWR."},{"key":"atypb22","unstructured":"Pertussis Surveillance Report - 8\/12\/05. 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