{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:11:26Z","timestamp":1777525886910,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2007,12,5]],"date-time":"2007-12-05T00:00:00Z","timestamp":1196812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>The objective of this study was to determine the impact of glucocorticoid exposure on lumbar spine bone mineral density (BMD) in children while concurrently measuring their calcium intake, serum 25-OH vitamin D levels, and physical activity. Forty-three patients (4-18 years) with renal glomerular diseases, dermatomyositis, inflammatory bowel disease, juvenile rheumatoid arthritis, post\u2014solid organ transplant, and Duchenne muscular dystrophy were studied. All received at least 5 mg per day of prednisone for more than 6 months. The mean BMD z score was 0 \u00b1 0.2 (range, \u22123.8 to +3.3) with 2 patients (5%) having z scores less than \u22122. The mean daily calcium intake was 1147 \u00b1 145 g, with 1 patient having hypovitaminosis D (&lt;15 ng\/mL). The mean physical activity level was 7.8 \u00b1 0.8 h\/wk. The small reductions in BMD observed in our population suggest that screening is likely not warranted in all children with chronic glucocorticoid exposure.<\/jats:p>","DOI":"10.1177\/0009922807311732","type":"journal-article","created":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T21:10:21Z","timestamp":1206997821000},"page":"469-475","source":"Crossref","is-referenced-by-count":21,"title":["Bone Mineral Density in Children Exposed to Chronic Glucocorticoid Therapy"],"prefix":"10.1177","volume":"47","author":[{"given":"Valeria C.","family":"Cohran","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Memorial Hospital, Chicago, Illinois,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Griffiths","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition and the General Clinical Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Heubi","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition and the General Clinical Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,12,5]]},"reference":[{"key":"atypb1","volume-title":"Fast Facts on Osteoporosis. 2006","author":"National Osteoporosis Foundation.","year":"2007"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.9.798"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807303390502"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.1.104"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070081"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650061113"},{"issue":"1","key":"atypb7","first-page":"S231","volume":"19","author":"Zemel BS","year":"2004","journal-title":"J Bone Miner Res"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200009)43:9<1960::AID-ANR6>3.0.CO;2-J"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70309-9"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.50071"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040367"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70058-2"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.6.1446"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.2.317"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00182.2004"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.1.257"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.5.913"},{"key":"atypb18","volume-title":"Osteoporosis prevention, diagnosis, and therapy","author":"National Institutes of Health.","year":"2000"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0009922807311732","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0009922807311732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:27:40Z","timestamp":1777393660000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0009922807311732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1177\/0009922807311732"],"URL":"https:\/\/doi.org\/10.1177\/0009922807311732","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,5]]}}}