{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:12:58Z","timestamp":1777525978327,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T00:00:00Z","timestamp":1222905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>Background Cleidocranial dysplasia (CCD) is an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature. It is caused by mutations of the transcription factor RUNX2, which is known as a major regulator of bone differentiation.<\/jats:p>\n                  <jats:p>Objective To report on 3 Chinese pediatric cases of CCD with an emphasis on the clinical presentation and diagnostic modalities.<\/jats:p>\n                  <jats:p>Case Summary 3 Chinese children were admitted to our hospital because of short stature. All the children had hypoplastic clavicles, absent calvarium, open fontanel, and messy palmprint. Screening laboratory test results for bone mineral density, free thyroxine, and thyroid stimulating hormone were all normal. One child had mental retardation. Two were hereditary, and 1 was sporadic.<\/jats:p>\n                  <jats:p>Conclusion These results showed that CCD should be suspected in patients with short stature and poor clavicles, calvarium, or teeth. Timely recognition and hereditary tendency counseling is required and useful.<\/jats:p>","DOI":"10.1177\/0009922808323107","type":"journal-article","created":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T20:34:18Z","timestamp":1222979658000},"page":"194-198","source":"Crossref","is-referenced-by-count":22,"title":["Cleidocranial Dysplasia: Report of 3 Cases and Literature Review"],"prefix":"10.1177","volume":"48","author":[{"family":"Zheng Shen","sequence":"first","affiliation":[{"name":"Department of Medicine, the Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Chao Chun Zou","sequence":"additional","affiliation":[{"name":"Department of Medicine, the Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Rong Wang Yang","sequence":"additional","affiliation":[{"name":"Department of Medicine, the Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Zheng Yan Zhao","sequence":"additional","affiliation":[{"name":"Department of Medicine, the Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,10,2]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1469-8749.1975.tb03507.x","volume":"4","author":"Siggers DC","year":"1975","journal-title":"Dev Med Child Neurol"},{"key":"atypb2","unstructured":"Gorlin RJ, Cohen MM, Levin LS Syndromes of the Head and Neck. 3rd ed. New York, NY: Oxford University Press; 1990:249-253."},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80260-3"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1038\/ng0797-307"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1086\/302622"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.12.2311"},{"key":"atypb7","first-page":"177","volume":"36","author":"Mundlos S.","year":"1999","journal-title":"J Med Genet"},{"key":"atypb8","volume-title":"Online Mendelian Inheritance in Man. MIM number 119600","author":"Omim."},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.1.71"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80257-3"},{"key":"atypb11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF00521301","volume":"98","author":"Schuch P.","year":"1967","journal-title":"Z Kinderheilkd"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.121.1.5"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-24-286-549"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320420307"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320460605"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0009922808323107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0009922808323107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:28:02Z","timestamp":1777393682000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0009922808323107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1177\/0009922808323107"],"URL":"https:\/\/doi.org\/10.1177\/0009922808323107","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,2]]}}}