{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T08:11:34Z","timestamp":1794211894640,"version":"4.8.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2010,8,19]],"date-time":"2010-08-19T00:00:00Z","timestamp":1282176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>Background. The authors sought to determine the prevalence, risk factors, and clinical impact of complications associated with outpatient parenteral antimicrobial therapy (OPAT) in children. Methods. A cohort of patients \u226418 years old with infections, who received OPAT were evaluated retrospectively. Antibiotic-associated complications (AACs), catheter-associated complications (CACs), and unplanned medical care visits were the main outcome measures. Results. Overall, 36 complications (25 CACs and 11 AACs) occurred in 32 of 98 patients. Mean age of patients, race, gender, and infecting organism did not differ between study groups. The use of OPAT for osteomyelitis was associated with complications (odds ratio = 2.69; 95% confidence interval = 0.99-7.35; P = .05). All patients, except for 4 who had complications, clinically improved by the end of OPAT. Unplanned medical visits occurred in 17 patients, 15 of which were because of CACs. Conclusion. Complications occurred commonly in children receiving OPAT and resulted in unplanned medical visits.<\/jats:p>","DOI":"10.1177\/0009922810374210","type":"journal-article","created":{"date-parts":[[2010,8,19]],"date-time":"2010-08-19T20:49:28Z","timestamp":1282250968000},"page":"1038-1043","source":"Crossref","is-referenced-by-count":33,"title":["Complications Associated With Outpatient Parenteral Antibiotic Therapy in Children"],"prefix":"10.1177","volume":"49","author":[{"given":"Jennifer","family":"Le","sequence":"first","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA, Miller Children's Hospital and Long Beach Memorial Medical Center, Long Beach, CA, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"San Agustin","sequence":"additional","affiliation":[{"name":"Miller Children's Hospital and Long Beach Memorial Medical Center, Long Beach, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvin A.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Loma Linda University, School of Pharmacy, Loma Linda, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu T.","family":"Tran","sequence":"additional","affiliation":[{"name":"Long Beach Memorial Medical Center, Long Beach, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice C.","family":"Adler-Shohet","sequence":"additional","affiliation":[{"name":"University of California, Irvine School of Medicine, Irvine, CA, USA, Pediatric Infectious Diseases, Children's Hospital of Orange County, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,8,19]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1086\/420939"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.204.3.9280235"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.90.6.806"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200105000-00015"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1994.00420160070009"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.2.e4"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-200207000-00017"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1465"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1177\/0009922806290328"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31817d32f2"},{"issue":"2","key":"atypb11","first-page":"CD004979","author":"Rojas MX","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0596"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1177\/0009922806289081"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e3181b2b860"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e3181ab472d"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0009922810374210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0009922810374210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:25:08Z","timestamp":1777393508000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0009922810374210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,19]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1177\/0009922810374210"],"URL":"https:\/\/doi.org\/10.1177\/0009922810374210","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,19]]}}}