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Children (2 to 12 years) meeting enrollment criteria were randomized 1:1 to receive antibiotic treatment in 2 urban outpatient clinics in Egypt and Croatia. Results: A total of 558 children (Croatia = 166, Egypt = 392) were randomized, with 368 evaluable in an intention-to-treat (ITT) analysis, and 272 evaluable in the per protocol (PP) analysis. In Croatia, ITT and PP treatment success rates were comparable for IM BPG and amoxicillin (2.5% difference vs 1.1% difference, respectively). In Egypt, amoxicillin was not comparable with IM BPG in ITT analysis (15.1% difference), but was comparable in PP analysis (-9.3% difference). Conclusion: If compliance is a major issue, a single dose of IM BPG may be preferable for treatment of GAS pharyngitis.<\/jats:p>","DOI":"10.1177\/0009922810394838","type":"journal-article","created":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T20:54:01Z","timestamp":1297457641000},"page":"535-542","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment of Streptococcal Pharyngitis With Once-Daily Amoxicillin Versus Intramuscular Benzathine Penicillin G in Low-Resource Settings: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"50","author":[{"given":"Anne W.","family":"Rimoin","sequence":"first","affiliation":[{"name":"UCLA School of Public Health, Los Angeles, CA, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole A.","family":"Hoff","sequence":"additional","affiliation":[{"name":"UCLA School of Public Health, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa L.","family":"Fischer Walker","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala S.","family":"Hamza","sequence":"additional","affiliation":[{"name":"Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Vince","sequence":"additional","affiliation":[{"name":"University Hospital for Infectious Diseases, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naglaa Abdel","family":"Rahman","sequence":"additional","affiliation":[{"name":"Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasa","family":"Andrasevic","sequence":"additional","affiliation":[{"name":"University Hospital for Infectious Diseases, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soha","family":"Emam","sequence":"additional","affiliation":[{"name":"Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dubravka","family":"Vukelic","sequence":"additional","affiliation":[{"name":"University Hospital for Infectious Diseases, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevine","family":"Elminawi","sequence":"additional","affiliation":[{"name":"Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadeer Abdel","family":"Ghafar","sequence":"additional","affiliation":[{"name":"Fayoum University, Al Fayoum, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia L. 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