{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:12:19Z","timestamp":1777525939462,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T00:00:00Z","timestamp":1360886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Background. Insulin resistance increases type 2 diabetes risk in obese adolescents. Thus, quantitative tools measuring insulin sensitivity and secretion are important for risk assessment. Methods. Forty-four obese pubertal adolescents underwent oral glucose tolerance test (OGTT) and frequently sampled intravenous glucose tolerance test (FSIGT). We correlated OGTT-derived whole body sensitivity index (WBISI) with FSIGT-derived insulin sensitivity index (Si). Insulinogenic index (IGI) from OGTT was compared with acute insulin response to glucose (AIRg) from FSIGT. Results. Fasting insulin ( r = \u2212.64, P &lt; .0005) and glucose ( r = \u2212.39 P \u2264 .0005) predicted Si. The OGTT-derived index WBISI correlated with the FSIGT-derived Si ( r = .608, P &lt; .0005). IGI correlated with AIRg from FSIGT ( r = .704, P &lt; .0005). Conclusions. OGTT-based measures correlated with FSIGT-derived measures of insulin sensitivity and secretion. In particular, we demonstrated that WBISI can be a reliable alternative to FSIGT-derived Si in clinical settings where OGTT is a more feasible option.<\/jats:p>","DOI":"10.1177\/0009922812472251","type":"journal-article","created":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T06:46:54Z","timestamp":1360910814000},"page":"247-253","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of Oral and Intravenous Glucose Tolerance Test Derived Sensitivity and Secretory Indices in Obese Adolescents"],"prefix":"10.1177","volume":"52","author":[{"given":"Preneet C.","family":"Brar","sequence":"first","affiliation":[{"name":"New York University School of Medicine, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorit","family":"Koren","sequence":"additional","affiliation":[{"name":"Pritzker School of Medicine, University of Chicago, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavana","family":"Pendurthi","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine E. 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