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We describe the clinical variability that gave rise to the suspicion of CZS in 3 newborn patients in the south of Mexico with active transmission of Zika. All of them presented Zika RNA by reverse transcription\u2013polymerase chain reaction and positive antibodies for IgM by enzyme-linked immunosorbent assay. None of the mothers tested positive for active viremia, only one mother had Zika-symptoms and titers of Zika-positive IgM. Intrauterine growth restriction, brain disruption sequence, and intracranial calcifications are the clinical characteristics common in all. One patient had neural tube defect and other, arthrogryposis. Because the majority of pregnant women will be asymptomatic to Zika, we must be alert to the clinical variability of the birth defects associated to pregnancy Zika infection. Reports of clinical cases encourage the medical community to make diagnostic decisions.<\/jats:p>","DOI":"10.1177\/0009922817738341","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T01:10:43Z","timestamp":1511140243000},"page":"927-936","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Birth Defects Associated With Congenital Zika Virus Infection in Mexico"],"prefix":"10.1177","volume":"57","author":[{"given":"Silvina Noem\u00ed","family":"Contreras-Capetillo","sequence":"first","affiliation":[{"name":"Hospital General Agust\u00edn O\u2019Hor\u00e1n, Secretar\u00eda de Salud de Yucat\u00e1n, Yucatan, Mexico"},{"name":"Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Aut\u00f3noma de Yucat\u00e1n, Yucatan, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Valad\u00e9z-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Aut\u00f3noma de Yucat\u00e1n, Yucatan, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Manrique-Saide","sequence":"additional","affiliation":[{"name":"Campus de Ciencias Biol\u00f3gicas y Agropecuarias, Universidad Aut\u00f3noma de Yucat\u00e1n, Yucatan, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Eduardo","family":"Carca\u00f1o-Castillo","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Aut\u00f3noma de Yucat\u00e1n, Yucatan, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freddy","family":"Pacheco-Tugores","sequence":"additional","affiliation":[{"name":"Hospital General Agust\u00edn O\u2019Hor\u00e1n, Secretar\u00eda de Salud de Yucat\u00e1n, Yucatan, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirian Alonso Moshe","family":"Barrera-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Servicios particulares de Anatomopatolog\u00eda, ANAPAT, Yucatan, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Pinto-Escalante","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Aut\u00f3noma de Yucat\u00e1n, Yucatan, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Lliteras-Card\u00edn","sequence":"additional","affiliation":[{"name":"Hospital General Agust\u00edn O\u2019Hor\u00e1n, Secretar\u00eda de Salud de Yucat\u00e1n, Yucatan, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Alfredo","family":"Hoil-Parra","sequence":"additional","affiliation":[{"name":"Hospital General Agust\u00edn O\u2019Hor\u00e1n, Secretar\u00eda de Salud de Yucat\u00e1n, Yucatan, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"C\u00e1ceres-Sol\u00eds","sequence":"additional","affiliation":[{"name":"ISSSTE Hospital Regional de M\u00e9rida, Yucatan, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"Pav\u00eda-Ruz","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Aut\u00f3noma de Yucat\u00e1n, Yucatan, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11,19]]},"reference":[{"key":"bibr1-0009922817738341","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602412"},{"key":"bibr2-0009922817738341","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6505e2"},{"key":"bibr3-0009922817738341","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6507e1"},{"key":"bibr4-0009922817738341","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805715"},{"key":"bibr5-0009922817738341","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw302"},{"key":"bibr6-0009922817738341","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-016-1384-0"},{"key":"bibr7-0009922817738341","unstructured":"Secretar\u00eda de Salud. 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