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Our goal was to compare the clinical responses of patients with ESBL UTI and non-ESBL UTI who received empiric third-generation cephalosporins. A retrospective analysis was performed on data collected between June 1, 2013, and June 30, 2017, from children aged 0 days to 19 years old who presented to NYU Langone Long Island Hospital\u2019s pediatric ED and\/or were admitted with a UTI caused by Enterobacteriaceae. There was no significant difference in median length of fever duration. However, ESBL patients had significantly longer hospital stays, higher 30-day readmission rate, and higher 7-day revisit rate. It is reasonable to maintain an empiric UTI antibiotic choice rather than selecting a broad-spectrum antibiotic, such as carbapenem for children at high risk of ESBL UTI.<\/jats:p>","DOI":"10.1177\/00099228221129029","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T01:55:41Z","timestamp":1665021341000},"page":"338-344","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Outcomes of Children With Extended-spectrum \u00df -Lactamase Urinary Tract Infection Receiving Discordant Empiric Antibiotic: A Comparative Study of Fever Duration, Length of Stay, and Readmissions"],"prefix":"10.1177","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-3490","authenticated-orcid":false,"given":"Xhesika","family":"Begaj","sequence":"first","affiliation":[{"name":"NYU Long Island School of Medicine, Mineola, NY, 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