{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:33:47Z","timestamp":1777527227426,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>Opioid-induced constipation is a common problem in critically ill children requiring sedation. Naloxegol is an oral U.S. Food and Drug Administration (FDA)-approved peripherally acting mu-opioid receptor antagonist for chronic opioid-induced constipation use in adults, but data on its use in children are lacking. We performed a retrospective analysis of critically ill children that had received naloxegol for opioid-induced constipation at our institution. Of the 45 patients studied, mean stool frequency increased significantly from 0.63 \u00b1 0.12 stools per day to 1.71 \u00b1 0.13 stools per day after starting naloxegol (95% confidence interval [CI]: [0.75, 1.4], P &lt; .001). There was no significant difference in the mean Withdrawal Assessment Tool 1 (WAT-1) score in the 24 hours before and after receiving the first dose (95% CI: [-0.25, 0.40], P = .63). This suggests naloxegol is effective in increasing stool output in critically ill children receiving opioids without an increase in opioid-withdrawal symptoms. It may be an effective adjunctive therapy for this population.<\/jats:p>","DOI":"10.1177\/00099228221142129","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:28:57Z","timestamp":1670459337000},"page":"721-724","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Naloxegol for Treatment of Opioid-Induced Constipation in the Pediatric Intensive Care Unit"],"prefix":"10.1177","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-9294","authenticated-orcid":false,"given":"Ethan L.","family":"Gillett","sequence":"first","affiliation":[{"name":"Arkansas Children\u2019s Hospital, Little Rock, AR, USA"},{"name":"University of Arkansas for Medical Sciences, Little Rock, AR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clint A.","family":"Layes","sequence":"additional","affiliation":[{"name":"Arkansas Children\u2019s Hospital, Little Rock, AR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Crawley","sequence":"additional","affiliation":[{"name":"Arkansas Children\u2019s Hospital, Little Rock, AR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Schexnayder","sequence":"additional","affiliation":[{"name":"Arkansas Children\u2019s Hospital, Little Rock, AR, USA"},{"name":"University of Arkansas for Medical Sciences, Little Rock, AR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"bibr1-00099228221142129","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000225371.10446.8F"},{"issue":"12","key":"bibr2-00099228221142129","first-page":"2726","volume":"35","author":"van der Spoel JI","year":"2007","journal-title":"Crit Care Med"},{"key":"bibr3-00099228221142129","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12899"},{"key":"bibr4-00099228221142129","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003194"},{"key":"bibr5-00099228221142129","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.25.040185.001341"},{"key":"bibr6-00099228221142129","first-page":"425","volume":"71","author":"Coluzzi F","year":"2005","journal-title":"Minerva Anestesiol"},{"key":"bibr7-00099228221142129","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.19-2-s23"},{"key":"bibr8-00099228221142129","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310246"},{"key":"bibr9-00099228221142129","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000216421.72002.09"},{"key":"bibr10-00099228221142129","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/pxz165"},{"key":"bibr11-00099228221142129","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.10.003"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00099228221142129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00099228221142129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00099228221142129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:32:25Z","timestamp":1777393945000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00099228221142129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,7]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1177\/00099228221142129"],"URL":"https:\/\/doi.org\/10.1177\/00099228221142129","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,7]]}}}