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Cardiopulmonary phenotypes were examined in a cohort of 1248 children with DS. Aptamer-based proteomic analysis of blood was performed in a subset (n = 120) of these children. By the age of 10 years, half of the patients in this cohort (n = 634, 50.8%) had co-occurring pulmonary diagnoses. That proteins and related pathways were distinct between children with pulmonary diagnoses and those with cardiac disease and\/or PH may indicate that pulmonary diagnoses appear to occur independently of cardiac disease and PH. Heparin sulfate-glycosaminoglycandegradation, nicotinate metabolism, and elastic fiber formation were ranked highest in the group with pulmonary diagnoses.<\/jats:p>","DOI":"10.1177\/00099228231179453","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T04:53:14Z","timestamp":1686545594000},"page":"474-481","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiopulmonary Phenotypes and Protein Signatures in Children With Down Syndrome"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0924-9342","authenticated-orcid":false,"given":"Emily M.","family":"DeBoer","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA"},{"name":"Children\u2019s Hospital Colorado, Aurora, CO, USA"},{"name":"Linda Crnic Institute for Down Syndrome, University of Colorado School of 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