{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:35:46Z","timestamp":1777527346726,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>We aimed to describe the frequency of treatment failure and associated risk factors for treatment failure amongst neonates with skin and soft tissue infections (SSTIs). We conducted a retrospective cohort study of neonates 0 to 28 days old with uncomplicated SSTIs presenting to the emergency department of a quaternary care children\u2019s hospital from 2009 to 2017. Data were collected via chart review. Skin and soft tissue infections included the following: cellulitis, abscess, mastitis, perirectal SSTI, carbuncle, and furuncle. Of the 202 neonates in the study, most were term, afebrile with mastitis, or perirectal SSTI. Treatment failure occurred in 8% (17\/202) of neonates receiving oral antibiotics; 10 of these neonates had perirectal SSTIs and 2 had clindamycin and methicillin-resistant Staphylococcus aureus. Neonates with treatment failure had increased odds of having perirectal SSTIs (odds ratio [OR] = 4.08, 95% confidence interval [CI] = 1.46-11.31). Further studies are needed to identify strategies to prevent treatment failure in neonates with perirectal SSTIs.<\/jats:p>","DOI":"10.1177\/00099228231189132","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T01:43:53Z","timestamp":1690335833000},"page":"689-696","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Factors for Treatment Failure in Neonates With Skin and Soft Tissue Infection: A Retrospective Cohort Study"],"prefix":"10.1177","volume":"63","author":[{"given":"Purva","family":"Patel","sequence":"first","affiliation":[{"name":"Divisions of Pediatric Hospital Medicine, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine E.","family":"Foster","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases and Pediatrics, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"Stimes","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases and Pediatrics, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX, USA"},{"name":"Department of Pharmacy, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Rin","family":"Lee","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Hospital Medicine, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX, USA"},{"name":"Department of Pharmacy, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6138-5923","authenticated-orcid":false,"given":"Sowdhamini S.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Hospital Medicine, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"bibr1-00099228231189132","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.583"},{"key":"bibr2-00099228231189132","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31826caaac"},{"key":"bibr3-00099228231189132","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2014-0232"},{"key":"bibr4-00099228231189132","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000001584"},{"key":"bibr5-00099228231189132","doi-asserted-by":"publisher","DOI":"10.1007\/BF00561477"},{"key":"bibr6-00099228231189132","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.94102s11107"},{"key":"bibr7-00099228231189132","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198814040-00001"},{"key":"bibr8-00099228231189132","doi-asserted-by":"publisher","DOI":"10.3390\/children2020244"},{"key":"bibr9-00099228231189132","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxz161"},{"key":"bibr10-00099228231189132","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz252"},{"key":"bibr11-00099228231189132","unstructured":"World Health Organization. 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