{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:40:04Z","timestamp":1777527604748,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"St Johns Research Society"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Renal histologic changes in congenital ureteropelvic junction obstruction (UPJO), although well documented, are sparsely studied in children. This study aims to establish a histological grading depending on the glomerular and tubulo-interstitial changes in hydronephrotic kidneys and determine correlation with age at surgery and impact on function post-pyeloplasty. A renal cortical wedge biopsy was obtained after pyeloplasty and histological changes were graded from 1 to 4. A total of 47 viable biopsies from 57 children showed grade 1 changes in 10, grade 2 in 7, grade 3 in 27, and grade 4 in 3. Age at surgery, histological grade, and changes in differential renal function (DRF) were statistically analyzed. Younger age, near normal histology, and those with changes in 1 domain had preserved DRF pre-operatively. Renal histology and overall grade showed positive correlation with pre-operative DRF. However, no statistically significant association was noted with age at surgery or change in post-operative DRF.<\/jats:p>","DOI":"10.1177\/00099228241261489","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T08:20:39Z","timestamp":1718785239000},"page":"271-277","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Renal Histopathological Changes in Children With Congenital Ureteropelvic Junction Obstruction"],"prefix":"10.1177","volume":"64","author":[{"given":"Mahin","family":"Mundra","sequence":"first","affiliation":[{"name":"St. John\u2019s Medical College, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suravi","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. John\u2019s Medical College, Bangalore, India"},{"name":"Department of Pathology, Kalinga Institute of Medical Sciences, Bhubaneswar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DevAnand","family":"Galagali","sequence":"additional","affiliation":[{"name":"St. John\u2019s Medical College, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Michael Raj","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, St. John\u2019s Medical College, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6658-035X","authenticated-orcid":false,"given":"Attibele Mahadevaiah","family":"Shubha","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, St. John\u2019s Medical College Hospital, Bangalore, Karnataka, India"},{"name":"Department of Pediatric Surgery, St. John\u2019s National Academy of Health Sciences, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"bibr1-00099228241261489","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(21)01232-5"},{"key":"bibr2-00099228241261489","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199508000-00102"},{"key":"bibr3-00099228241261489","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)45332-8"},{"key":"bibr4-00099228241261489","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)42034-9"},{"key":"bibr5-00099228241261489","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.10.018"},{"key":"bibr6-00099228241261489","doi-asserted-by":"publisher","DOI":"10.5812\/numonthly.28051"},{"key":"bibr7-00099228241261489","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2042.2002.00467.x"},{"key":"bibr8-00099228241261489","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67142-8"},{"key":"bibr9-00099228241261489","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000004"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00099228241261489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00099228241261489","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00099228241261489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:33:43Z","timestamp":1777394023000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00099228241261489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,19]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/00099228241261489"],"URL":"https:\/\/doi.org\/10.1177\/00099228241261489","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,19]]}}}