{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:40:21Z","timestamp":1777527621618,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Neonatal Pharmacy Small Research Grant by the Pediatric Pharmacy Association"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>\n                    The aim of this study was to compare sequelae and acute kidney injury (AKI) occurrence among patients with necrotizing enterocolitis (NEC) after changing institutional guidelines replacing vancomycin with ampicillin for gram-positive coverage. This was a retrospective, single-center cohort analysis of patients from 2016-2020 (n = 73) with NEC at a surgical neonatal intensive care unit with a high community prevalence of methicillin-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA). Multivariate logistic regression was utilized to assess associations. Twenty-five (34%) patients had at least 1 sequela related to NEC. Ampicillin containing regimens were not associated with any sequelae type or AKI. Postmenstrual age &lt; 29 weeks at diagnosis ([OR] 5.8 [1.2\u201328.8],\n                    <jats:italic>P<\/jats:italic>\n                    = .03; and receipt of vasopressors [OR] 3.3 [1.1-10.2],\n                    <jats:italic>P<\/jats:italic>\n                    = .04) were independently associated with sequalae. Stage III NEC was independently associated with AKI, OR 10.6 (2\u201355.6),\n                    <jats:italic>P<\/jats:italic>\n                    = .005. In conclusion, ampicillin-containing regimens are effective for NEC management at our institution despite a high prevalence of MRSA.\n                  <\/jats:p>","DOI":"10.1177\/00099228241271938","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:12:09Z","timestamp":1723680729000},"page":"401-407","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comparison of Sequelae After a Practice Change From Vancomycin to Ampicillin Containing Antibiotic Regimens for Necrotizing Enterocolitis"],"prefix":"10.1177","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2189-6475","authenticated-orcid":false,"given":"James Hunter","family":"Fly","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA"},{"name":"Le Bonheur Children\u2019s Hospital, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelley R.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA"},{"name":"Le Bonheur Children\u2019s Hospital, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra R.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Le Bonheur Children\u2019s Hospital, Memphis, TN, USA"},{"name":"Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bindiya","family":"Bagga","sequence":"additional","affiliation":[{"name":"Le Bonheur Children\u2019s Hospital, Memphis, TN, USA"},{"name":"Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay J.","family":"Talati","sequence":"additional","affiliation":[{"name":"Le Bonheur Children\u2019s Hospital, Memphis, TN, USA"},{"name":"Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy S.","family":"Stultz","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA"},{"name":"Le Bonheur Children\u2019s Hospital, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10244"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.02.013"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2020.02.046"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00040"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.119"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.07.036"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1543"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2640"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.1204"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30343-9"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198404263101707"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3468(80)80775-5"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040346"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000405"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/649554"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000615"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1693429"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2141"},{"key":"e_1_3_3_20_2","first-page":"1","article-title":"KDIGO clinical practice guideline for acute kidney injury","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group","year":"2012","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney Inter Suppl. 2012;2:1-138.","journal-title":"Kidney Inter Suppl"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1086\/655698"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/20.3.421"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3809-y"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1459553"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/25.4.679"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/32.2.325"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00099228241271938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00099228241271938","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00099228241271938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:33:46Z","timestamp":1777394026000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00099228241271938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,14]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/00099228241271938"],"URL":"https:\/\/doi.org\/10.1177\/00099228241271938","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,14]]}}}