{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T16:52:44Z","timestamp":1794243164821,"version":"4.9.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Public service development and reform pilot project of Beijing Medical Research Institute","award":["BMR2019-11"],"award-info":[{"award-number":["BMR2019-11"]}]},{"name":"Beijing Municipal Administration of Hospitals Incubating Program","award":["PX2023048"],"award-info":[{"award-number":["PX2023048"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n                    The objective of this study was to evaluate the effectiveness and cost-effectiveness of different therapy regimens for girls with central precocious puberty (CPP). This study retrospectively analyzed CPP girls from 2013 to 2021 and grouped them into GnRHa, Mixed, and GnRHa+GH based on therapy regimen. While comparing the differences among these groups, initial age and bone age of GnRHa group girls were significantly lower than Mixed and GnRHa+GH groups, but their growth level was significantly higher (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .05). In the Mixed group, starting with GnRHa alone, the predicted adult height improvement (\u0394PAH) decreased to \u22121.0 cm in the second year, prompting addition of growth hormone (GH) therapy in the third year, resulting in a \u0394PAH increase to 3.0 cm. At therapy completion, final predicted adult heights (PAHs) were similar among the groups at 155.6 to 156.7 cm, with \u0394PAH between 5.8 and 6.5 cm and no significant intergroup differences (\n                    <jats:italic>P<\/jats:italic>\n                    &gt; .05). Younger CPP girls with greater height can begin therapy with GnRHa alone. Consideration of combining GH therapy depends on growth velocity and PAH during treatment.\n                  <\/jats:p>","DOI":"10.1177\/00099228241288977","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T12:41:07Z","timestamp":1729341667000},"page":"712-718","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Three Therapy Regimens and Their Cost-effectiveness for Girls With Central Precocious Puberty: A Real-World Clinical Study"],"prefix":"10.1177","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6979-2980","authenticated-orcid":false,"given":"Hua-Hong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Growth and Development, Capital Institute of Pediatrics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Growth and Development, Capital Institute of Pediatrics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Growth and Development, Capital Institute of Pediatrics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-021-04022-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2019.01.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000491103"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-017-2898-8"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/abr.abr_121_19"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1708650"},{"issue":"6","key":"e_1_3_3_8_2","first-page":"412","article-title":"[Consensus statement for the diagnosis and treatment of central precocious puberty (2015)]","volume":"53","author":"Subspecialty Group of Endocrinologic Hereditary and Metabolic Diseases the Society of Pediatrics Chinese Medical Association; Editorial Board Chinese Journal of Pediatrics","year":"2015","unstructured":"Subspecialty Group of Endocrinologic Hereditary and Metabolic Diseases the Society of Pediatrics Chinese Medical Association; Editorial Board Chinese Journal of Pediatrics. 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Reference values of differences between TW3-C RUS and TW3-C Carpal bone ages of children from five cities of China. Zhonghua Er Ke Za Zhi. 2008;46(11):851-855.","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.818061"},{"issue":"1","key":"e_1_3_3_13_2","first-page":"4","article-title":"Comparison of bone age and adult height predicted by the different methods in Chinese children aged 3~16 years","volume":"12","author":"Shao-Yan Z","year":"2012","unstructured":"Shao-Yan Z, Ji-Ye Z, Lijuan L, et al. Comparison of bone age and adult height predicted by the different methods in Chinese children aged 3~16 years. J Chin Med Res. 2012;12(1):4-14. 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