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Chromosomal rearrangements can be associated with syndromes causing neurodevelopmental delay, autism spectrum disorder, and variable dysmorphic features. This article presents the clinical and molecular characteristics of a 2-year-old male child with neurodevelopmental delay who was diagnosed with a chromosomal rearrangement due to a 15q24 duplication (dup15q24). The 15q24 locus presents controversy between the phenotype associated with duplication and deletion, thus posing a challenge in differential diagnosis for both. The phenotypes of autism spectrum disorder and pediatric patients with language delay should be evaluated by a multidisciplinary team comprising genetics, pediatrics, and pediatric neurology to shorten the diagnostic odyssey for patients with rare diseases and to impact the quality of life of the patient and their family.<\/jats:p>","DOI":"10.1177\/00099228241296235","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T02:49:11Z","timestamp":1732243751000},"page":"764-770","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["15q24 Duplication: A Case Report of Neurodevelopmental Delay"],"prefix":"10.1177","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9890-1412","authenticated-orcid":false,"given":"Agust\u00edn","family":"C\u00e1mara-Dom\u00ednguez","sequence":"first","affiliation":[{"name":"School of Medicine, Universidad Marista de M\u00e9rida, M\u00e9rida, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8582-6471","authenticated-orcid":false,"given":"Alexandra Margaret","family":"Stuart-Aguiar","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad Marista de M\u00e9rida, M\u00e9rida, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1940-4106","authenticated-orcid":false,"given":"Nicte-H\u00e1 Asunci\u00f3n","family":"Fuentes-Canto","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad Marista de M\u00e9rida, M\u00e9rida, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6424-1400","authenticated-orcid":false,"given":"Andrea","family":"Cervera-Rosado","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad Marista de M\u00e9rida, M\u00e9rida, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3478-4427","authenticated-orcid":false,"given":"Cuauhtli Nacxitl","family":"Azotla-Vilchis","sequence":"additional","affiliation":[{"name":"Molecular Biology and Massive Sequencing Laboratory, Genos M\u00e9dica, Centro Especializado en Gen\u00e9tica, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz del Carmen","family":"M\u00e1rquez-Quiroz","sequence":"additional","affiliation":[{"name":"Molecular Biology and Massive Sequencing Laboratory, Genos M\u00e9dica, Centro Especializado en Gen\u00e9tica, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3049-7604","authenticated-orcid":false,"given":"Rodrigo","family":"Vargas-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Pediatric Neurology, Cl\u00ednica de M\u00e9rida, M\u00e9rida, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-3813","authenticated-orcid":false,"given":"Silvina Noem\u00ed","family":"Contreras-Capetillo","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Hospital General Dr. Agust\u00edn O\u2019Hor\u00e1n, Secretar\u00eda de Salud de Yucat\u00e1n, M\u00e9rida, Mexico"},{"name":"Genetics Laboratory, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"issue":"9","key":"e_1_3_3_2_2","first-page":"641","article-title":"Desarrollo neurol\u00f3gico normal del ni\u00f1o","volume":"19","author":"Gomez AD","year":"2015","unstructured":"Gomez AD, Pulido VI, Fiz PL. 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