{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:13:24Z","timestamp":1787620404128,"version":"build-2736575974"},"reference-count":23,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    This single-center cross-sectional retrospective chart review sought to define the prevalence of neuropsychiatric (NP) disorders among children with non-alcoholic fatty liver disease (NAFLD) compared to the general population. The prevalence rate of NP disorders was determined at diagnosis among children evaluated from 2006 to 2016. The NP disorder prevalence rates were compared to those reported in the 2016 National Survey of Children\u2019s Health (NSCH). 24.3% of 254 children with NAFLD reported to have at least 1 NP disorder compared to 16.9% of those in NSCH (relative risk [RR] = 1.44;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .0001). More children had intellectual disability (ID) (4.5% vs 0.8%; RR = 5.43,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .0001), depression (3.9% vs 2.2%; RR = 1.82,\n                    <jats:italic>P<\/jats:italic>\n                    = .0009), or autism spectrum disorder (ASD) (3.3% vs 2.0%; RR = 1.67,\n                    <jats:italic>P<\/jats:italic>\n                    = .047) in the Boston Children\u2019s Hospital (BCH) NAFLD cohort. The prevalence of 1 NP disorder was 29.4% in our cohort compared to 22.3% in NSCH (RR = 1.32;\n                    <jats:italic>P<\/jats:italic>\n                    = .007). Children with NAFLD have a higher rate of NP disorders compared to the general population.\n                  <\/jats:p>","DOI":"10.1177\/00099228251330113","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T13:43:32Z","timestamp":1743083012000},"page":"1274-1280","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["A Cross-Sectional Retrospective Review of Neuropsychiatric Comorbidities in Children With Non-Alcoholic Fatty Liver Disease"],"prefix":"10.1177","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2613-3077","authenticated-orcid":false,"given":"Katherine F.","family":"Sweeny","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Institutional Centers for Clinical and Translational Research, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shavonne","family":"Osiakwan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4787-5547","authenticated-orcid":false,"given":"Cosette","family":"Scott","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen M.","family":"Jonas","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1212"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140908"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2018.09.001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15395"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2019.34.e199"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12165"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002401"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04181.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.07.055"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/cch.12129"},{"key":"e_1_3_2_12_2","volume-title":"Paper presented at the Digestive Diseases Week","author":"Lee CK","unstructured":"Lee CK, Jonas MM. High prevalence of psychiatric and attention-deficit\/ hyperactivity disorders in children with NAFLD at Children\u2019s Hospital Boston 1995-2005: a retrospective study. Paper presented at the Digestive Diseases Week; May 14, 2007; Washington, DC."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000003024"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_3_2_17_2","unstructured":"National Survey of Children\u2019s Health. Child and family health measures national performance and outcome measures and subgroups [format eg. SAS\/SPSS\/Stata] codebook version [insert version] data resource center for child and adolescent health supporte.2016. https:\/\/www.childhealthdata.org"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi188"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000002605"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12518"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dhjo.2014.10.005"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0000000000000602"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12024"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.02.062"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00099228251330113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00099228251330113","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00099228251330113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:34:10Z","timestamp":1777394050000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00099228251330113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,27]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/00099228251330113"],"URL":"https:\/\/doi.org\/10.1177\/00099228251330113","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,27]]}}}