{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:27:35Z","timestamp":1787034455616,"version":"build-2736575974"},"reference-count":29,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>There are limited number of studies in the literature reporting the effect of subclinical hypothyroidism (SH) on insulin resistance and glucose metabolism in children. This study compared insulin, glucose and Homeostasis Model Assessment (HOMA-IR) values in 50 patients with SH and 50 healthy subjects. However, no significant difference was found between the groups. In addition, no significant correlation was observed between the TSH and fT4 levels and blood glucose, insulin and HOMA-IR values in patients with SH. Our study showed that SH does not lead to insulin resistance. Weight gain may be higher than normal in patients with SH. More comprehensive studies are needed for the long-term metabolic and cardiovascular effects of SH.<\/jats:p>","DOI":"10.1177\/00099228251333302","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T05:55:26Z","timestamp":1744437326000},"page":"1365-1369","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Is Insulin Resistance Present in Children With Subclinical Hypothyroidism?"],"prefix":"10.1177","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7004-6803","authenticated-orcid":false,"given":"Amine","family":"Aktar Karakaya","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9809-0977","authenticated-orcid":false,"given":"Edip","family":"Unal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3289-6887","authenticated-orcid":false,"given":"Asl\u0131","family":"Be\u015fta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-6305","authenticated-orcid":false,"given":"Ozan","family":"Kap\u00e7ay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Dicle University, Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0051"},{"issue":"11","key":"e_1_3_2_3_2","first-page":"1049","article-title":"Subclinical hypothyroidism in childhood and adolescense","volume":"27","author":"Catli G","year":"2014","unstructured":"Catli G, Abac\u0131 A, B\u00fcy\u00fckgebiz A, Bober E. Subclinical hypothyroidism in childhood and adolescense. J Pediatr Endocr Met. 2014;27(11-12):1049-1057.","journal-title":"J Pediatr Endocr Met"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00109"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.115948"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0797"},{"issue":"9","key":"e_1_3_2_7_2","first-page":"147","article-title":"Study of insulin resistance in subclinical hypothyroidism","volume":"4","author":"Vyakaranam S","year":"2014","unstructured":"Vyakaranam S, Vanaparthy S, Nori S, Palarapu S, Bhongir AV. Study of insulin resistance in subclinical hypothyroidism. Int J Health Sci Res. 2014;4(9):147-153.","journal-title":"Int J Health Sci Res"},{"issue":"7","key":"e_1_3_2_8_2","first-page":"488","article-title":"Metabolic syndrome prevalence in subclinic and overt hypothyroid patients and the relation among metabolic syndrome parameters","volume":"34","author":"Erdogan M","year":"2011","unstructured":"Erdogan M, Canataroglu A, Ganidagli S, Kulaksizoglu M. Metabolic syndrome prevalence in subclinic and overt hypothyroid patients and the relation among metabolic syndrome parameters. J Endocrinol Invest. 2011;34(7):488-492.","journal-title":"J Endocrinol Invest"},{"issue":"2","key":"e_1_3_2_9_2","article-title":"Effect of insulin resistance in assessing the clinical outcome of clinical and subclinical hypothyroid patients","volume":"9","author":"B UU","year":"2015","unstructured":"B UU, Mn S, Km S, Prashant A, Doddamani P, Sv S. Effect of insulin resistance in assessing the clinical outcome of clinical and subclinical hypothyroid patients. J Clin Diag Res. 2015;9(2):OC01-OC04.","journal-title":"J Clin Diag Res"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.2183"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.4526"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.3.170"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3345\/cep.2019.01536"},{"issue":"2","key":"e_1_3_2_14_2","first-page":"24","article-title":"Serum magnesium level and its relation with insulin resistance in obese children","volume":"8","author":"Abac\u0131 A","year":"2010","unstructured":"Abac\u0131 A, H\u0131zl\u0131 \u015e, \u00d6zdemir O, et al. Serum magnesium level and its relation with insulin resistance in obese children. G\u00fcncel Pediatri. 2010;8(2):24-29.","journal-title":"G\u00fcncel Pediatri"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/152850"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/289503"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0478"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1696-4"},{"issue":"6","key":"e_1_3_2_19_2","first-page":"329","article-title":"Insulin resistance and glucose levels in subjects with subclinical hypothyroidism","volume":"27","author":"Khan SH","year":"2017","unstructured":"Khan SH, Fazal N, Ijaz A, et al. Insulin resistance and glucose levels in subjects with subclinical hypothyroidism. J Coll Physicians Surg Pak. 2017;27(6):329-333.","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/07435800.2015.1108332"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.104085"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2012.05.007"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.316.7560"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.100"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.13926"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.IJEM_153_17"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.3319"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.11.013"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.3.775"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-05822014000100010"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00099228251333302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00099228251333302","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00099228251333302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:04:39Z","timestamp":1787033079000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00099228251333302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,12]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/00099228251333302"],"URL":"https:\/\/doi.org\/10.1177\/00099228251333302","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,12]]}}}