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We included children with precocious puberty as the study population. The enrolled children were randomly assigned to either the Internet group, which received Internet-based Comprehensive Disease Management, or the control group, which received the standard care model. This study included a total of 78 children with precocious puberty. The Internet-based comprehensive disease management model demonstrated significant advantages, particularly in strengthening the self-management capabilities of the children with precocious puberty. In addition, it empowered parents with a heightened sense of self-determination in caring for their children. 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