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Brain SPECT imaging and responses to antibiotic treatments were recorded. Patients had more than 5 symptoms lasting more than 6 months. A history of tick bite and\/or rash was present in 40%. Western blots were more sensitive than enzyme immunoassays screening tests. Brain SPECT scans were abnormal in 65% of patients. Treatment with specific antibiotics over time resolved the illness in most children. A clinical diagnosis can be made based on the combination of certain persisting symptoms, and serologic and nuclear medicine studies support the clinical diagnosis. Treatment with specific antibiotics over a number of months is helpful as a diagnostic test and lead to resolution of symptoms in most patients.<\/jats:p>","DOI":"10.1177\/00099228251371991","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T09:07:47Z","timestamp":1757581667000},"page":"70-75","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Persisting Lyme Disease in the Pediatric Population"],"prefix":"10.1177","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0852-5034","authenticated-orcid":false,"given":"Sam T.","family":"Donta","sequence":"first","affiliation":[{"name":"Department of Medicine (Infectious Disease), University of Connecticut Health Center, Boston University Medical Center, Falmouth Hospital, Falmouth, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200102"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7043737"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.91.2.456"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610243351703"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.4.905"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.5.609"},{"issue":"8","key":"e_1_3_2_8_2","first-page":"2025","article-title":"Lyme arthritis in children and adolescents: outcome 12 months after initiation of antibiotic therapy","volume":"27","author":"Bentas W","year":"2000","unstructured":"Bentas W, Karch H, Huppertz HI. 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