{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:01:54Z","timestamp":1789426914558,"version":"build-2803163510"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    Immunoglobulin A vasculitis (IgAV) is a common immune complex-mediated systemic small vessel vasculitis in children. Gastrointestinal (GI) involvement significantly impacts early prognosis and may precede the appearance of purpura, complicating timely diagnosis. We retrospectively analyzed 195 cases of children diagnosed with IgAV from June 2019 to April 2024, among whom 62 cases had GI involvement. Clinical and laboratory data were collected. Children in the IgAV GI involvement group exhibited lower rates of arthritis\/arthralgia and significantly higher levels of neutrophil-to-lymphocyte ratio (NLR) (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .002, OR = 1.455), platelet count (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .020, OR = 1.005), and uric acid (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .017, OR = 1.005), with lower immunoglobulin G (IgG) (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .004, OR = .818) levels. Multivariate analysis identified NLR, platelet count, uric acid, and IgG as independent predictors. The combined model showed good discrimination (area under the curve [AUC] = 0.753) and high specificity (93.2%). Elevated NLR, platelet count, uric acid, and reduced IgG are independent risk factors for GI involvement in pediatric IgAV and may facilitate early risk stratification.\n                  <\/jats:p>","DOI":"10.1177\/00099228251389785","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T08:26:38Z","timestamp":1762417598000},"page":"349-357","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of Clinical Features and High-Risk Factors of Gastrointestinal Involvement in Children With IgA Vasculitis"],"prefix":"10.1177","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2719-0619","authenticated-orcid":false,"given":"Dan","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Paediatrics, The Affiliated Changzhou No. 2 People\u2019s Hospital of Nanjing Medical University, Changzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, The Affiliated Changzhou No. 2 People\u2019s Hospital of Nanjing Medical University, Changzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00421"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060515621446"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835d8e2a"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex158"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2005.08.007"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200109000-00001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12403"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-014-0148-8"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v7.i3.66"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1179\/2046905512Y.0000000005"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.116657"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez041"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1025335"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.074641"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-013-0869-6"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000519665"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1055-8"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1991.01410310059008"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.1998.00263.x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3897\/folmed.66.e113993"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13157"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1755-7682-5-2"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027551"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.29782"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7778"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073636"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.668974"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2019.39.4.345"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12089"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256478"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107454"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.24953\/turkjpediatr.2024.4797"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn501113-20200326-00142"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39107"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.25011\/cim.v46i2.40274"},{"issue":"1","key":"e_1_3_3_37_2","first-page":"30","article-title":"Serum IgG subclasses and IgM imbalances in adult IgA mesangial glomerulonephritis and idiopathic Henoch-Schoenlein purpura","volume":"75","author":"Rostoker G","year":"1989","unstructured":"Rostoker G, Pech MA, Del Prato S, et al Serum IgG subclasses and IgM imbalances in adult IgA mesangial glomerulonephritis and idiopathic Henoch-Schoenlein purpura. 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