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Children with macrolide-resistant M. pneumoniae had a longer period of coughing prior to diagnosis (+ 3.9 days, p=0.048), a longer duration of illness (+ 5.4 days, p=0.011) and earlier resolution of fever after initiation of doxycycline (- 0.92 days, p=0.025) compared to those without macrolide resistant M. pneumoniae.<\/jats:p>","DOI":"10.1177\/00099228251392096","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:40:26Z","timestamp":1765881626000},"page":"153-157","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Increased Macrolide-Resistant\n                    <i>Mycoplasma pneumoniae<\/i>\n                    Infections and Response to Doxycycline in Midwest United States"],"prefix":"10.1177","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4916-7306","authenticated-orcid":false,"given":"Miltiadis","family":"Douvoyiannis","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Pediatric Infectious Diseases, Altru Health System, Grand Forks, ND, USA"},{"name":"University of North Dakota, Altru Health System, Grand Forks, ND, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanner E.","family":"Rothstein","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"},{"name":"Department of Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00968-19"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7307a3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.20949"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piae117"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02432-21"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10020192"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13549"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis784"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182a25c71"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.200017"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.02102.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004568"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2021.09.010"},{"key":"e_1_3_3_15_2","first-page":"905","volume-title":"Red Book: 2018 Report of the Committee on Infectious Diseases","author":"American Academy of Pediatrics","year":"2018","unstructured":"American Academy of Pediatrics. 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