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Information about the prevalence of use in a pediatric primary care population has been limited. Youth aged 12 to 17 attending a well-child visit completed screening for past year e-cigarette, cigarette, cannabis, and alcohol use, as well as depression and anxiety symptoms. We examined e-cigarette-use prevalence, frequency, and relationship to demographics, mental health symptoms, and other substance use. Among 9740 patients, 8.2% reported past-year e-cigarette use. Males (7.2%) were less likely than females (9.2%) to use e-cigarettes, while more frequent use was associated with more frequent cannabis, alcohol, and cigarette use, as well as elevated depression and anxiety symptoms. Sex differences support a recent trend toward young females using e-cigarettes at higher rates than males. Polysubstance use was common, highlighting the importance of regular screening for all substances and feasible interventions for this setting.<\/jats:p>","DOI":"10.1177\/00099228251399041","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T02:06:08Z","timestamp":1767060368000},"page":"499-505","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Mental Health Correlates of Electronic Cigarette Use Among Pediatric Primary Care Patients"],"prefix":"10.1177","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8685-6699","authenticated-orcid":false,"given":"Jordan M.","family":"Braciszewski","sequence":"first","affiliation":[{"name":"Center for Health Policy and Health Services Research, Henry Ford Health, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Elmali","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elyse N.","family":"Llamocca","sequence":"additional","affiliation":[{"name":"Center for Health Policy and Health Services Research, Henry Ford Health, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa M.","family":"Vanderziel","sequence":"additional","affiliation":[{"name":"Center for Health Policy and Health Services Research, Henry Ford Health, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadley","family":"Cameron-Carter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Henry Ford Health, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy M.","family":"Loree","sequence":"additional","affiliation":[{"name":"Center for Health Policy and Health Services Research, Henry Ford Health, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"E-Cigarette Use Among Youth and Young Adults: A Report of the Surgeon General","author":"US Department of Health and Human Services","year":"2016","unstructured":"US Department of Health and Human Services. 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