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A retrospective analysis was conducted on 162 children aged 3 to 14 years who underwent gastroscopy at our Digestive Endoscopy Center between January 2022 and June 2024. Based on the sedation regimen used, patients were categorized into 2 groups: the propofol group (n = 78, sedated with propofol alone) and the combination group (n = 84, sedated with midazolam and propofol). Baseline characteristics, sedation efficacy, recovery parameters, intra-procedural vital signs, incidence of adverse reactions, use of sedative drugs, and procedure-related times were compared between the 2 groups. Propofol monotherapy offers rapid recovery, less impact on vital signs, and improved turnover efficiency, making it a potentially more suitable sedation strategy for pediatric diagnostic gastroscopy in clinical practice.<\/jats:p>","DOI":"10.1177\/00099228251407412","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T09:49:19Z","timestamp":1767001759000},"page":"556-565","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Efficacy of Different Sedation Regimens in Pediatric Diagnostic Gastroscopy: A Retrospective Controlled Study"],"prefix":"10.1177","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7131-015X","authenticated-orcid":false,"given":"Qin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Nantong First People\u2019s Hospital (Affiliated Hospital 2 of Nantong University), Nantong, 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