{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:40:32Z","timestamp":1792482032529,"version":"4.5.0"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Pediatr (Phila)"],"abstract":"<jats:p>\n                    This retrospective cohort study investigated the effect of intravenous methylprednisolone on immune outcomes in 624 children with\n                    <jats:italic toggle=\"yes\">Mycoplasma pneumoniae<\/jats:italic>\n                    pneumonia (MPP) admitted from April 2023 to April 2025. Data were retrospectively extracted from electronic medical records. Based on treatment received, patients were divided into control (azithromycin-based therapy) and observation (additional methylprednisolone) groups. After treatment, the observation group showed significantly higher CD4\u207a and CD4\u207a\/CD8\u207a levels, lower CD8\u207a levels, greater reductions in IL-6 and IL-8, and greater increase in IL-10 compared with controls (all\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Symptom resolution times were significantly shorter in the observation group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Adverse reaction rates were similar between groups (11.54% vs 15.38%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &gt; .05). Adding intravenous methylprednisolone to standard therapy was associated with improved immune and inflammatory markers, faster symptom resolution, and good tolerability in children with MPP. Prospective trials are needed to validate these findings.\n                  <\/jats:p>","DOI":"10.1177\/00099228261481634","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:18:01Z","timestamp":1792304281000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Intravenous Methylprednisolone With Immune Response and Clinical Outcomes in Children With\n                    <i>Mycoplasma pneumoniae<\/i>\n                    Pneumonia: A Retrospective Cohort Study"],"prefix":"10.1177","author":[{"given":"Junmei","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Dongyang Women and Children\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dongyang Women and Children\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7735-8187","authenticated-orcid":false,"given":"Wenbin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dongyang Women and Children\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004946"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1135228"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S466994"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1378445"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-024-05519-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002529"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.23812\/20-317-L"},{"issue":"2","key":"e_1_3_3_9_2","first-page":"83","volume":"45","author":"Subspecialty Group of Respiratory Diseases, Society of Pediatrics, Chinese Medical Association; Editorial Board of Chinese Journal of Pediatrics Guidelines for the management of community-acquired pneumonia in children (Trial Implementation) (Part 1)","year":"2007","unstructured":"Subspecialty Group of Respiratory Diseases, Society of Pediatrics, Chinese Medical Association; Editorial Board of Chinese Journal of Pediatrics Guidelines for the management of community-acquired pneumonia in children (Trial Implementation) (Part 1). Chin J Pediatr. 2007;45(2):83-90. 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