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The triad of a period of rapid growth, advanced bone age and absence of precocious sexual development is characteristic of this syndrome and is seen rarely in other conditions. Extensive growth hormone and other pertinent assays, including circadian studies, failed to demonstrate any excess of endocrine secretions.<\/jats:p>","DOI":"10.1177\/000992287000901112","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"662-667","source":"Crossref","is-referenced-by-count":15,"title":["Cerebral Gigantism"],"prefix":"10.1177","volume":"9","author":[{"given":"John W.","family":"Mace","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Naval Hospital, San Diego, Calif"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald W.","family":"Gotlin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado School of Medicine; previously on active duty, Naval Hospital, San Diego, Calif. 92134"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1970,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196407162710301"},{"key":"atypb2","first-page":"357","volume":"117","author":"Ott, J.E.","year":"1969","journal-title":"Amer. 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