{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:54:30Z","timestamp":1777524870160,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[1977,11,1]],"date-time":"1977-11-01T00:00:00Z","timestamp":247190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1977,11]]},"abstract":"<jats:p>A bleeding syndrome due to severe prothrombin complex deficiency is reported in 93 infants. Most were breast fed (98 per cent), aged 2 weeks to 1 year and there were no serious preceding or associated diseases. Hemor rhagic diathesis, pallor and mild hepatomegaly were the major manifesta tions. The incidence of intracr nial bleeding was strikingly high (63 per cent) particularly with subdural and subarachnoid hemorrhage.<\/jats:p>\n                  <jats:p>Acute onset, short course and rapid clinical and laboratory improvement after vitamin K therapy were observed. Mortality rate was 35 per cent but has been reduced to 17 per cent since 1969. The location of bleeding, prompt diagnosis and early treatment are the major factors affecting prognosis.<\/jats:p>\n                  <jats:p>Severe prothrombin complex deficiency due to vitamin K deficiency ac counted for the pathogenesis of bleeding. Possible causes of vitamin K deficiency were discussed but definite conclusions could not be drawn.<\/jats:p>","DOI":"10.1177\/000992287701601106","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"992-998","source":"Crossref","is-referenced-by-count":44,"title":["A Bleeding Syndrome in Infants due to Acquired Prothrombin Complex Deficiency"],"prefix":"10.1177","volume":"16","author":[{"given":"P.","family":"Bhanchet","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Department of Pathology, Ramathibodi Hospital, and Department of Pediatrics, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tuchinda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Pathology, Ramathibodi Hospital, and Department of Pediatrics, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hathirat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Pathology, Ramathibodi Hospital, and Department of Pediatrics, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Visudhiphan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Pathology, Ramathibodi Hospital, and Department of Pediatrics, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Bhamaraphavati","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Pathology, Ramathibodi Hospital, and Department of Pediatrics, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bukkavesa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Pathology, Ramathibodi Hospital, and Department of Pediatrics, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1977,11,1]]},"reference":[{"key":"atypb1","volume-title":"The Eleventh Congress of International Society of Hematology","author":"Bhanchet, P."},{"key":"atypb2","first-page":"173","volume":"16","author":"Lovric, V.A.","year":"1967","journal-title":"Ann. Med."},{"key":"atypb3","first-page":"72","volume":"9","author":"Chan, M.C.K.","year":"1967","journal-title":"J. Singapore Pediatr. Soc."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(70)80404-8"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1950.3.6.365"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-191304000-00004"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-193510000-00009"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/29.6.525"},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0002-9378(16)38744-0","volume":"64","author":"Schneider, C.L.","year":"1952","journal-title":"Am. J. Obstet. Gynecol."},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.6.1.23"},{"key":"atypb11","unstructured":"Owren, P.A.: One-stage method for specific prothrombin determination: The coagulation of blood. Tocantins, L. W., Ed. New York, Grune & Stratton, 1955, p. 94."},{"key":"atypb12","unstructured":"Biggs, R., and Macfarlane, R.G. : Human Blood Coagulation and Its Disorders, 3rd ed. Philadelphia, F. A. Davis company, 1962, p. 138."},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.3109\/00365515109060600"},{"key":"atypb14","first-page":"637","volume":"41","author":"Langdell, R.D.","year":"1953","journal-title":"J. Lab. Clin. Med."},{"key":"atypb15","first-page":"936","volume":"55","author":"Barrow, E.M.","year":"1960","journal-title":"J. Lab. Clin. Med."},{"key":"atypb16","first-page":"24","volume":"2","author":"Bachmann, F.","year":"1958","journal-title":"Thromb. Diath. Hem."},{"key":"atypb17","volume-title":"Arrest of bleeding","author":"Koskam, J.","year":"1954"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1951.01570100066012"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1542\/peds.44.5.745"},{"key":"atypb20","first-page":"35","volume":"1","author":"Lovric, V.A.","year":"1971","journal-title":"J. Med."},{"key":"atypb21","first-page":"3","volume":"1","author":"Whitaker, J.A.","year":"1969","journal-title":"Chiengmai Med. Bull."}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992287701601106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992287701601106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:24:30Z","timestamp":1777393470000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992287701601106"}},"subtitle":["A Survey of 93 Affected Infants"],"short-title":[],"issued":{"date-parts":[[1977,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1977,11]]}},"alternative-id":["10.1177\/000992287701601106"],"URL":"https:\/\/doi.org\/10.1177\/000992287701601106","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,11]]}}}