{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:46:04Z","timestamp":1777524364768,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1980,9,1]],"date-time":"1980-09-01T00:00:00Z","timestamp":336614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1980,9]]},"abstract":"<jats:p>\n                    The clinical syndrome known as persistent fetal circulation, or persistent pulmonary hypertension of the newborn, is characterized by maintenance of a high pulmonary vascular resistance after birth. The small pulmonary arteries of the fetus have a thick muscular medial layer; they are very reactive, being actively constricted by the low P\n                    <jats:sub>O2<\/jats:sub>\n                    levels normally present during fetal life. The pulmonary vascular smooth muscle layer is hypertrophied in conditions that result in chronic fetal hypoxia, or a maintained increase in pulmonary arterial pressure. Normally, pulmonary vasodilation occurs rapidly after birth, partly related to physical expansion with gas, but mainly due to the increased P\n                    <jats:sub>O2<\/jats:sub>\n                    associated with ventilation with air. Based on these developmental considerations, the factors responsible for an increased pulmonary vascular resistance after birth may be classified in three main groups: (A) Acute vaso constriction due to postnatal hypoxia and aggravated by acidemia; (B) Prenatal increase in pulmonary vascular smooth muscle development; and (C) Decreased cross sectional area of the pulmonary vascular bed due to inadequate numbers of vessels. The various mechanisms that may promote these responses are presented.\n                  <\/jats:p>","DOI":"10.1177\/000992288001900902","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T18:00:38Z","timestamp":1217268038000},"page":"585-590","source":"Crossref","is-referenced-by-count":81,"title":["High Pulmonary Vascular Resistance After Birth"],"prefix":"10.1177","volume":"19","author":[{"given":"Abraham M.","family":"Rudolph","sequence":"first","affiliation":[{"name":"Departments of Pediatrics, Physiology, Obatetrics, Gynecotogy, and Reproductive Sciences, University of California, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1980,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.53.1.144"},{"key":"atypb2","first-page":"121","volume":"71","author":"Naeye RL","year":"1961","journal-title":"Arch Pathol"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2214\/ajr.129.5.777","volume":"129","author":"Reid L.","year":"1977","journal-title":"Am J Roentgenol"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.39.4.536"},{"key":"atypb5","first-page":"11","volume":"115","author":"Rudolph AM","year":"1977","journal-title":"Am Rev Resp Dis"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1542\/peds.48.4.528","volume":"48","author":"Goldberg SJ","year":"1971","journal-title":"Pediatrics"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80022-5"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.60.2.360"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(63)90054-7"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.38.5.418"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(76)90640-2"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80454-5"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(77)90197-7"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80453-3"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288001900902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288001900902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:23:18Z","timestamp":1777393398000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992288001900902"}},"subtitle":["I. Pathophysiologic Considerations and Etiologic Classification"],"short-title":[],"issued":{"date-parts":[[1980,9]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1980,9]]}},"alternative-id":["10.1177\/000992288001900902"],"URL":"https:\/\/doi.org\/10.1177\/000992288001900902","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,9]]}}}