{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:53:13Z","timestamp":1784969593505,"version":"3.55.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1981,5,1]],"date-time":"1981-05-01T00:00:00Z","timestamp":357523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1981,5]]},"abstract":"<jats:p>The incidence of the hand-foot syndrome (dactylitis) has been studied in a group of. 233 children with homozygous sickle cell (SS) disease followed prospectively from birth. Dactylitis affected 45% of the children by the age of 2 years, with most cases occurring before this age. Episodes were significantly more common during colder months of the year, similar to the seasonal rela tionship previously noted in painful crises. Comparison of hematologic indices at age 6 months in patients with and without development of dactylitis indicated a lower fetal hemoglobin and higher reticulocyte counts in affected patients. The occurrence of dactylitis in combination with low fetal hemoglobin may serve to identify high-risk patients with SS disease.<\/jats:p>","DOI":"10.1177\/000992288102000501","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T18:00:38Z","timestamp":1217268038000},"page":"311-317","source":"Crossref","is-referenced-by-count":42,"title":["Observations on the Natural History of Dactylitis in Homozygous Sickle Cell Disease"],"prefix":"10.1177","volume":"20","author":[{"given":"M.C.G.","family":"Stevens","sequence":"first","affiliation":[{"name":"Medical Research Council Laboratories, University of the West Indies, Kingston, Jamaica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Padwick","sequence":"additional","affiliation":[{"name":"Medical Research Council Laboratories, University of the West Indies, Kingston, Jamaica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.R.","family":"Serjeant","sequence":"additional","affiliation":[{"name":"Medical Research Council Laboratories, University of the West Indies, Kingston, Jamaica"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1981,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/20.6.666"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.28.9.761"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1038\/1841877a0"},{"key":"atypb4","unstructured":"Dacie JV, Lewis SM: Practical Haematology. London, Churchill, 1968, pp 18-46"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.1"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-36-421-19"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197658080-00024"},{"key":"atypb8","first-page":"401","volume":"26","author":"Trowell HC","year":"1957","journal-title":"Q J Med"},{"key":"atypb9","first-page":"200","volume":"104","author":"Lambotte C.","year":"1962","journal-title":"Am J Dis Child"},{"key":"atypb10","first-page":"975","volume":"31","author":"Watson RJ","year":"1963","journal-title":"Pediatrics"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1177\/000992286400300214"},{"key":"atypb12","first-page":"241","volume":"10","author":"Konotey-Ahulu Fid","year":"1971","journal-title":"Ghana Med J"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5909.54"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6001.66"},{"key":"atypb15","first-page":"31","volume":"67","author":"Marsden PD","year":"1964","journal-title":"J Trop Med Hyg"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1970.tb01647.x"},{"key":"atypb17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0308-2261(21)00626-3","volume":"4","author":"Serjeant GR","year":"1975","journal-title":"Clin Haematol"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109720"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.65.1.29"},{"key":"atypb20","unstructured":"Hayes RJ, Serjeant GR: Unpublished observations."},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1979.tb03684.x"},{"key":"atypb22","unstructured":"Sewell A., Millard D., Serjeant GR: The interaction of alpha thalassemia with SS disease, The Red Cell. Edited by GJ Brewer. New York, Alan R Liss, Inc., 1978 , pp93-102"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80529-X"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288102000501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288102000501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:24:04Z","timestamp":1777393444000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992288102000501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1981,5]]}},"alternative-id":["10.1177\/000992288102000501"],"URL":"https:\/\/doi.org\/10.1177\/000992288102000501","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,5]]}}}