{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:53:07Z","timestamp":1777524787593,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1982,1,1]],"date-time":"1982-01-01T00:00:00Z","timestamp":378691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:p>Four infants with Down syndrome developed cor pulmonale and heart failure in association with chronic upper airway obstruction. Features of the sleep apnea syndrome were conspicuous; namely, noisy breathing with retraction, cyanosis and frequent apnea during sleep, and daytime lethargy and somnolence. The clinical picture masqueraded as cyanotic congenital heart disease. Arterial blood gas anal yses revealed alveolar hypoventilation, especially during sleep. The nature of the obstructive element was variable. Adenoidectomy provided partial relief in one patient, and tonsillectomy and adenoidectomy resulted in temporary improvement in two others. Three patients were markedly benefitted by tracheostomy. Func tional inspiratory pharyngeal closure was demonstrated fluorographically in one patient.<\/jats:p>\n                  <jats:p>Infants with Down syndrome may be predisposed to upper airway obstruction by virtue of hypoplasia of facial and oropharyngeal structures and generalized hypotonia. Additional obstructive elements may be contributed by hypertrophied lymphoid tissue, excessive secretions, and glossoptosis. Removal of the obstructive element is helpful, but functional obstruction may only be relieved by tracheos tomy.<\/jats:p>","DOI":"10.1177\/000992288202100104","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"25-29","source":"Crossref","is-referenced-by-count":79,"title":["Alveolar Hypoventilation and Cor Pulmonale Associated with Chronic Airway Obstruction in Infants with Down Syndrome"],"prefix":"10.1177","volume":"21","author":[{"given":"O. Robert","family":"Levine","sequence":"first","affiliation":[{"name":"College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Department of Pediatrics, and United Hospitals Medical Center, Newark, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moises","family":"Simpser","sequence":"additional","affiliation":[{"name":"College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Department of Pediatrics, and United Hospitals Medical Center, Newark, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1982,1,1]]},"reference":[{"key":"atypb1","volume-title":"Cor pulmonale, Disorders of the Respiratory Tract in Children","author":"Noonan, JA","year":"1977"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(69)90378-6"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1980.00330130047015"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80716-0"},{"key":"atypb5","volume-title":"Mongolism and Cretinism","author":"Benda CE","year":"1949"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(73)80155-2"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196706292762603"},{"key":"atypb8","first-page":"160","volume":"16","author":"Ardan GM","year":"1972","journal-title":"J Ment Defic Res"},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1542\/peds.63.2.261","volume":"63","author":"Tonkin SL","year":"1979","journal-title":"Pediatrics"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)81119-6"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197011000-00003"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1963.18.5.895"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1966.21.2.527"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(57)90314-5"},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1542\/peds.37.5.762","volume":"37","author":"Luke MJ","year":"1966","journal-title":"Pediatrics"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(65)80115-9"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.27.020176.002341"},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1542\/peds.63.6.837","volume":"63","author":"Guilleminault C.","year":"1979","journal-title":"Pediatrics"},{"key":"atypb19","first-page":"1217","volume":"8","author":"Coccagna G.","year":"1972","journal-title":"Bull Eur Physiopathol Respir"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1177\/000348947408300516"},{"key":"atypb21","first-page":"931","volume":"44","author":"Remmers FE","year":"1978","journal-title":"Am J Physiol"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197811022991801"},{"key":"atypb23","author":"Grover RF","year":"1971","journal-title":"Minerva Medica"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80142-9"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80718-0"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288202100104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288202100104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:24:17Z","timestamp":1777393457000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992288202100104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1177\/000992288202100104"],"URL":"https:\/\/doi.org\/10.1177\/000992288202100104","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}