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Reinfection with a new group A streptococcal serotype occurred in 13 patients, 12 developing 7 to 12 days afrer stopping therapy and 11 becoming symptomatic. Relapse with the same organism oc curred in 16 patients, only 5 (31%) of whom were symptomatic. Antibody titer rises, antibiotic resistance of group A organisms, presence of penicillinase- producing staphylococci, and lack of compliance were not related to re current infections. There were no significant differences between the failure rates of the four test drugs: penicillin V, 12%; benzathine\/procaine penicillin G, 12%; cefadroxil monohydrate, 5%; and erythromycin, 2%.<\/jats:p>","DOI":"10.1177\/000992288202100203","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"83-88","source":"Crossref","is-referenced-by-count":23,"title":["Treatment of Group A Streptococcal Pharyngitis in Children"],"prefix":"10.1177","volume":"21","author":[{"given":"Charles M.","family":"Ginsburg","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"JR","given":"George H.","family":"McCracken","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel B.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen D.","family":"Crow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben F.","family":"Dildy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Cope","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Zweighaft","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1982,2,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195807102590202"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(66)80248-2"},{"key":"atypb3","first-page":"22","volume":"31","author":"Stillerman M.","year":"1963","journal-title":"Am J Dis Child"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1971.02100170059005"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1972.02110110085005"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91832-2"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1203\/00006450-198012000-00041","volume":"14","author":"Schwartz R.","year":"1980","journal-title":"Pediatr Res"},{"key":"atypb8","first-page":"270","author":"Stillerman M.","year":"1971","journal-title":"Antimicrob Agents Chemother"},{"key":"atypb9","first-page":"127","volume":"1","author":"Stitterman M.","year":"1978","journal-title":"Curr Chemother"},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1542\/peds.37.3.467","volume":"37","author":"Quie PG","year":"1966","journal-title":"Pediatrics"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.57.4.571"},{"key":"atypb12","first-page":"149","volume":"2","author":"Moody MD","year":"1965","journal-title":"Health Lab Sci"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.11.6.1087"},{"key":"atypb14","unstructured":"Zar G.: Biostatistical Statistical Analysis. 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