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Twenty-four received indomethacin and 12 of these met the criteria for response; 23 received the placebo and two met the criteria for response (p &lt; 0.01). Subsequent surgical ligation for symptomatic PDA was required in 13 of 23 in the placebo group and 4 of 24 in the indomethacin group (p &lt; 0.01). When administered early, indomethacin is moderately effective in closing PDA in premature infants.<\/jats:p>","DOI":"10.1177\/000992288202100404","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"217-220","source":"Crossref","is-referenced-by-count":23,"title":["Indomethacin for Closure of Patent Ductus Arteriosus in Prematures"],"prefix":"10.1177","volume":"21","author":[{"given":"Martha D.","family":"Mullett","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Community Medicine, West Virginia University Medical Center, Morgantown, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas W.","family":"Croghan","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Community Medicine, West Virginia University Medical Center, Morgantown, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Z.","family":"Myerberg","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Community Medicine, West Virginia University Medical Center, Morgantown, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Krall","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Community Medicine, West Virginia University Medical Center, Morgantown, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Neal","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Community Medicine, West Virginia University Medical Center, Morgantown, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1982,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80910-X"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1159\/000455530"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197804001-00174"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80519-2"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80909-3"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80560-4"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80774-X"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1159\/000455528"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1159\/000455529"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80445-8"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198107093050203"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198107093050209"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288202100404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288202100404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:24:38Z","timestamp":1777393478000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992288202100404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,4]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1982,4]]}},"alternative-id":["10.1177\/000992288202100404"],"URL":"https:\/\/doi.org\/10.1177\/000992288202100404","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,4]]}}}