{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:29:59Z","timestamp":1791404999043,"version":"4.3.3"},"reference-count":20,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[1982,12,1]],"date-time":"1982-12-01T00:00:00Z","timestamp":407548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1982,12]]},"abstract":"<jats:p>Propoxyphene (Darvon\u00ae) and acetaminophen (Tylenol\u00ae) are widely prescribed analgesic agents. Both can cross the placenta, and propoxyphene can produce serious withdrawal symptoms in newborns. Neither propoxyphene nor acetam inophen is considered a teratogen, yet, three malformed infants who were an tenatally exposed to propoxyphene have previously been reported. We report a fourth case of an infant, with withdrawal symptoms and cranial-facial and digital malformations, born to a woman who used propoxyphene and acetaminophen throughout her pregnancy. We suggest the possibility that the antepartum use of propoxyphene and acetaminophen, in combination, may be teratogenic.<\/jats:p>","DOI":"10.1177\/000992288202101210","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"752-754","source":"Crossref","is-referenced-by-count":21,"title":["Propoxyphene and Acetaminophen"],"prefix":"10.1177","volume":"21","author":[{"given":"Nancy L.","family":"Golden","sequence":"first","affiliation":[{"name":"Departments of Pediatrics, Obstetrics and Gynecology, and the Perinatal Clinical Research Center, Cleveland Metropolitan General Hospital\/Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine C.","family":"King","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Obstetrics and Gynecology, and the Perinatal Clinical Research Center, Cleveland Metropolitan General Hospital\/Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Sokol","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Obstetrics and Gynecology, and the Perinatal Clinical Research Center, Cleveland Metropolitan General Hospital\/Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1982,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1177\/000992287301200808"},{"key":"atypb2","first-page":"2084","volume":"78","author":"Ente G.","year":"1978","journal-title":"NY State J Med"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1970.03170320024005"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80519-6"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1542\/peds.55.6.882","volume":"55","author":"Klein RB","year":"1975","journal-title":"Pediatrics"},{"key":"atypb6","unstructured":"Heinonen OP, Slone D., Shapiron S. 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Philadelphia: WB Saunders, 1973:36-57."},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(71)90005-6"},{"key":"atypb12","first-page":"1031","volume":"4","author":"Minneshita T.","year":"1970","journal-title":"Oyo Yakuri"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(75)90492-5"},{"key":"atypb14","first-page":"1058","volume":"106","author":"Ringrose Cad.","year":"1972","journal-title":"Con Med Assoc J"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1971.03190110069022"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1976.tb04941.x"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1980.tb02473.x"},{"key":"atypb18","unstructured":"Goodman LS, Gilman A. The Pharmacological Basis of Therapeutics. New York: MacMillan, 1970;108-12, 263-4,329-34."},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1007\/BF00563102"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1980.68"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288202101210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288202101210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:24:32Z","timestamp":1777393472000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992288202101210"}},"subtitle":["Possible Effects on the Fetus"],"short-title":[],"issued":{"date-parts":[[1982,12]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1982,12]]}},"alternative-id":["10.1177\/000992288202101210"],"URL":"https:\/\/doi.org\/10.1177\/000992288202101210","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,12]]}}}