{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:06:03Z","timestamp":1777525563102,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1986,1,1]],"date-time":"1986-01-01T00:00:00Z","timestamp":504921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:p>Premature adrenarche (PA) or isolated growth of sexual hair in young children, is a benign condition that may initially be confused with true precocious puberty or pathologic virilizing disorders. The clinical findings, family history, and serum concentrations of dehydroepiandrosterone sulfate (DHEA-S) were compared in 24 children with PA (79% black females) seen in a 2-year period and in an age-matched control group of 17 black females. Twenty three of 24 patients, but none of the controls, had an adult-type axillary odor. There was a positive family history of PA in only three of 24 children with PA, and in one of 17 controls. The mean serum DHEA-S was significantly higher in the PA children than in the controls, but there was a broad range of concentrations (10-143 \u03bcg\/dl), with values in 10 of 24 cases falling within the control range for age. We conclude that: (1) PA is a relatively common finding in black females between ages 3 and 8, (2) an axillary odor is almost always present in children with PA, and (3) determination of serum DHEA-S may be of some help in confirming the clinical impression of a modest increase in adrenal androgen secretion and in ruling out a more serious disorder. In most cases, however, the diagnosis of PA can be made on the basis of the history, physical examination, and lack of rapid progression over time; the use of laboratory tests to rule out a pathologic virilizing process may best be reserved for those children with very early onset, increased linear growth, or other signs of virilization.<\/jats:p>","DOI":"10.1177\/000992288602500105","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"28-34","source":"Crossref","is-referenced-by-count":25,"title":["Premature Adrenarche"],"prefix":"10.1177","volume":"25","author":[{"given":"Paul B.","family":"Kaplowitz","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Children's Medical Center, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice L.","family":"Cockrell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Medical Center, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reuben B.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Medical Center, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1542\/peds.10.4.426","volume":"10","author":"Silverman SH","year":"1952","journal-title":"Pediatrics"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1177\/000992286800700110"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-42-1-117"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0820342"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3928\/00904481-19810901-03","volume":"10","author":"Pang S.","year":"1981","journal-title":"Pediatr Ann"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80513-8"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-42-6-1005"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1080\/00032717208062119"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-47-3-572"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(71)80111-7"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196904172801606"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)81244-4"},{"key":"atypb13","unstructured":"Rosenfield RL The ovary and female sexual maturation. In: Kaplan SA, ed. Clinical pediatric and adolescent endocrinology. Philadelphia: W. B. Saunders, 1982, p. 247."},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1542\/peds.76.3.437","volume":"76","author":"Lee Pdk","year":"1985","journal-title":"Pediatrics"},{"key":"atypb15","first-page":"406","volume":"137","author":"Kaplowitz PB","year":"1983","journal-title":"Am J Dis Child"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-49-3-335"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80594-4"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198506000-00143"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-58-4-595"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288602500105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288602500105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:26:32Z","timestamp":1777393592000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992288602500105"}},"subtitle":["Clinical and Diagnostic Features"],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["10.1177\/000992288602500105"],"URL":"https:\/\/doi.org\/10.1177\/000992288602500105","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}