{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:10:44Z","timestamp":1777525844347,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1987,9,1]],"date-time":"1987-09-01T00:00:00Z","timestamp":557452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1987,9]]},"abstract":"<jats:p>Ninety-three children from four pediatric practices, with clinical and bacteriologic evidence of acute Group A beta-hemolytic streptococcal pharyngitis (GABHS) randomly received cefuroxime axetil (60 cases) or phenoxymethyl penicillin (33 cases). Cefuroxime axetil was given twice daily (125 mg). Phenoxymethyl penicillin was given three times daily (250 mg). The treatment groups were similar. Throat cultures were routine 2 to 7 days after the start of therapy and 2 days and 14 days after the end of therapy. The bacterial cure rates were 85 percent (51\/60) for cefuroxime axetil, and 88 percent (29\/33) for phenoxymethyl penicillin treated patients. Clinical results were comparable in both treatment groups. It was concluded that cefuroxime axetil given twice daily is as effective as phenoxymethyl penicillin given three times daily in producing bacteriologic eradication and clinical symptomatic improvement in children with GABHS.<\/jats:p>","DOI":"10.1177\/000992288702600904","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"453-458","source":"Crossref","is-referenced-by-count":22,"title":["A Multicenterg Randomized, Single-blind Evaluation of Cefuroxime Axetil and Phenoxymethyl Penicillin in the Treatment of Streptococcal Pharyngitis"],"prefix":"10.1177","volume":"26","author":[{"given":"Michael E.","family":"Pichichero","sequence":"first","affiliation":[{"name":"Elmwood Pediatric Group and Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank A.","family":"Disney","sequence":"additional","affiliation":[{"name":"Elmwood Pediatric Group and Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerson H.","family":"Aronovitz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Ginsburg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Health Science Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxwell","family":"Stillerman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, State University of New York at Stoneybrook, Stoneybrook, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-198306000-00001"},{"key":"atypb2","unstructured":"Jones RN, Thornsberry C. In vitro antimicrobial activity, physical characteristics and other microbiological features of cefuroxime: a new study and review. In: Moellering RC (ed). The clinical significance of the newer beta-lactam antibiotics: focus on cefuroxime. ADIS Press , New York: 1983;30-45."},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1983.tb04543.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.25.1.78"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80392-9"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1970112205"},{"key":"atypb7","first-page":"47","volume":"47","author":"Disney FA","year":"1971","journal-title":"Postgrad Med J"},{"key":"atypb8","first-page":"276","volume":"208","author":"Gau DW","year":"1972","journal-title":"Practitioner"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1972.02110110085005"},{"key":"atypb10","first-page":"1271","volume":"108","author":"Rabinovitch M.","year":"1973","journal-title":"CMAJ"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.6.4.501"},{"key":"atypb12","first-page":"38","volume":"50","author":"Derrick CW","year":"1974","journal-title":"Circulation"},{"issue":"4","key":"atypb13","first-page":"50","volume":"55","author":"Disney FA","year":"1979","journal-title":"Postgrad Med J"},{"issue":"11","key":"atypb14","first-page":"82","volume":"8","author":"Ginsburg CM","year":"1980","journal-title":"J Int Med Res"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1177\/000992288202100203"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/10.suppl_B.125"},{"key":"atypb17","doi-asserted-by":"crossref","volume-title":"A randomized, single-blind evaluation of cefadroxil and phenoxymethyl penicillin in the treatment of streptococcal pharyngitis","author":"Pichichero ME","DOI":"10.1128\/AAC.31.6.903"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1971.02100170059005"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91832-2"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/123.5.490"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1960.04020040355007"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196412312712705"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/12.6.599"},{"key":"atypb24","first-page":"4674","volume":"37","author":"Quie PG","year":"1966","journal-title":"Pediatrics"},{"key":"atypb25","doi-asserted-by":"crossref","volume-title":"Treatment of group A streptococcal pharyngitis in children","author":"Ginsburgh CM","DOI":"10.1177\/000992288202100203"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288702600904","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992288702600904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:27:32Z","timestamp":1777393652000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992288702600904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,9]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1987,9]]}},"alternative-id":["10.1177\/000992288702600904"],"URL":"https:\/\/doi.org\/10.1177\/000992288702600904","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,9]]}}}