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Some of the disorders lack peroxisomes in cells, while others have single or multiple peroxisomal enzymatic deficiencies despite the presence of normally appearing peroxisomes. The prototype of the peroxisomal disorders is Zellweger syndrome. X-linked adrenoleukodystrophy, neonatal adrenoleukodystrophy, infantile Refsum disease, hyperpipecolic acidemia and Refsum disease are some of the other disease entities presently classified as peroxisomal disorders. Accurate methods of pre- and postnatal diagnosis are available. Treatment strategies are being developed, but at this time prenatal diagnosis and appropriate genetic counseling is the best therapeutic intervention for those peroxisomal disorders characterized by profound neurologic handicap and early death.<\/jats:p>","DOI":"10.1177\/000992288702601001","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"497-504","source":"Crossref","is-referenced-by-count":7,"title":["Peroxisomal Disorders"],"prefix":"10.1177","volume":"26","author":[{"given":"Dinesh","family":"Talwar","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurology, University of Minnesota Medical School, Minneapolis, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth F.","family":"Swaiman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, University of Minnesota Medical School, Minneapolis, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,10,1]]},"reference":[{"key":"atypb1","volume-title":"Correlation of ultrastructural organization and function in normal and experimentally changed proximal convoluted tubule cells of the mouse kidney. 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