{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:39:23Z","timestamp":1777523963446,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1988,9,1]],"date-time":"1988-09-01T00:00:00Z","timestamp":589075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:p>A female infant with growth failure, microcephaly, hypertelorism, epicanthal folds, preauricular pit, congenital heart defect, hypotonia, and delayed development is reported. Trisomy 22 mosaicism (46,XX\/47,XX,+22) was found in cultured skin fibroblasts but not in blood lymphocytes. Trisomy restricted to skin fibroblasts is uncommon.<\/jats:p>\n                  <jats:p>Cytogenetic evaluation of a second tissue (preferably skin) is suggested in patients with physical and mental abnormalities who have normal blood chromosome studies.<\/jats:p>","DOI":"10.1177\/000992288802700908","type":"journal-article","created":{"date-parts":[[2008,6,26]],"date-time":"2008-06-26T19:42:29Z","timestamp":1214509349000},"page":"451-454","source":"Crossref","is-referenced-by-count":23,"title":["Trisomy 22 Mosaicism with Normal Blood Chromosomes"],"prefix":"10.1177","volume":"27","author":[{"given":"Mira L.","family":"Lessick","sequence":"first","affiliation":[{"name":"Section of Genetics, Rush-Presbyterian-St. Luke's Medical Center, 1750 West Harrison Street, Chicago, IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Szego","sequence":"additional","affiliation":[{"name":"Section of Genetics, Rush-Presbyterian-St. Luke's Medical Center, 1750 West Harrison Street, Chicago, IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W. K.","family":"Wong","sequence":"additional","affiliation":[{"name":"Section of Genetics, Rush-Presbyterian-St. Luke's Medical Center, 1750 West Harrison Street, Chicago, IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1988,9,1]]},"reference":[{"key":"atypb1","unstructured":"de Grouchy J., Turleau C. Clinical Atlas of Human Chromosomes. 2nd edition. New York: John Wiley & Sons , 1984;362."},{"key":"atypb2","doi-asserted-by":"crossref","unstructured":"Schinzel A. Catalogue of Unbalanced Chromosome Aberrations in Man. New York: Walter de Gruyter, 1984 ;733-4.","DOI":"10.1515\/9783112329047"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1978.tb02119.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.12.2.193"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.13.6.517"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1177\/000992287601500706"},{"key":"atypb7","unstructured":"Hsu Lyf, Hirschhorn K. The trisomy 22 syndrome and the cat eye syndrome. In: Yunis JJ, ed. New Chromosomal Syndromes. New York: Academic Press, 1977;339-68."},{"key":"atypb8","unstructured":"Feingold M., Pashayan H. Genetics and Birth Defects in Clinical Practice. Boston\/Toronto : Little, Brown, 1983;236."},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-0269-8"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00306562"},{"key":"atypb11","unstructured":"Zellweger H. , Simpson J. Chromosomes of Man. 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