{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:53:26Z","timestamp":1777524806063,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[1991,8,1]],"date-time":"1991-08-01T00:00:00Z","timestamp":681004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1991,8]]},"abstract":"<jats:p>Primary empty sella syndrome has been considered an infrequent finding in childhood. One hundred and twelve cases have been reported in children ages 0.7 to 18 years. The frequency of primary empty sella ranged from 1% to 58%. Endocrine abnormalities were described in nearly all , children while visual abnormalities were noted in only 6%. Growth hormone deficiency was the single most common hormonal dysfunction noted in children with primary empty sella. Precocious puberty has been rarely reported in association with primary empty sella. We report the case of a 7-1\/2 year old girl with gonadotropin dependent central precocious puberty and a partially empty sella who had no other hypothalamic-pituitary dysfunction. We suggest that pubertal abnormalities be included among the endocrine disorders potentially associated with the primary empty sella syndrome.<\/jats:p>","DOI":"10.1177\/000992289103000801","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T18:53:11Z","timestamp":1196103191000},"page":"466-471","source":"Crossref","is-referenced-by-count":11,"title":["Primary Empty Sella Syndrome in Childhood: Association with Precocious Puberty"],"prefix":"10.1177","volume":"30","author":[{"given":"Robert","family":"Rapaport","sequence":"first","affiliation":[{"name":"UMD-New Jersey Medical School and Children's Hospital of New Jersey, Newark, NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Logrono","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. Barnabas Medical Center, Livingston, NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,8,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1987.tb02494.x"},{"key":"atypb2","first-page":"540","volume":"18","author":"Shulman DI","year":"1946","journal-title":"J Pediatr"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/000992288402300804"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80648-9"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198709000-00026"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1080\/21548331.1989.11703823"},{"key":"atypb7","first-page":"473","volume":"39","author":"Dawod ST","year":"1984","journal-title":"Helv Paediatr Acta"},{"key":"atypb8","first-page":"49","volume":"42","author":"Querci F.","year":"1987","journal-title":"Helv Paediatr Acta"},{"key":"atypb9","first-page":"295","volume":"43","author":"Pocecco M.","year":"1988","journal-title":"Helv Paediatr Acta"},{"key":"atypb10","first-page":"92","volume":"196","author":"Fusco R.","year":"1988","journal-title":"A case report. Opthalmol"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1159\/000180918"},{"key":"atypb12","first-page":"335","volume":"42","author":"Surtees R.","year":"1987","journal-title":"Helv Paediatr Acta"},{"key":"atypb13","first-page":"1009","volume":"130","author":"Raiti S.","year":"1976","journal-title":"AJDC"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-4-633"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1007\/BF00442492"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198504000-00514"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197803302981302"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80302-9"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(86)90052-4"},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"219A","DOI":"10.1203\/00006450-198611000-00073","volume":"20","author":"Rapaport R.","year":"1986","journal-title":"Pediatr Res"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1986.tb03255.x"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80837-X"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1052432"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1007\/BF03349578"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82858-6"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289103000801","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289103000801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:24:20Z","timestamp":1777393460000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992289103000801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1991,8]]}},"alternative-id":["10.1177\/000992289103000801"],"URL":"https:\/\/doi.org\/10.1177\/000992289103000801","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,8]]}}}