{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:51:18Z","timestamp":1777524678744,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[1991,11,1]],"date-time":"1991-11-01T00:00:00Z","timestamp":688953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:p>Polyuria may result from either a water or a solute diuresis. Although the history and physical examination may provide clues to the cause of the polyuria, the definitive diagnosis requires laboratory tests which focus on the osmolality of the urine and serum in combination with the urine volume and the rate of excretion of osmoles. An isoosmolar or hyperosmolar urine is found in children with a solute diuresis or in normal children, whereas a hypoosmolar urine is found in children with a water diuresis. In the latter case, a low serum osmolality suggests primary polydipsia whereas a high serum osmolality suggests antidiuretic hormone (ADH) deficiency or insensitivity. A water deprivation test is necessary when the initial evaluation fails to establish the cause of polyuria. A vasopressin test enables the differentiation between neurogenic and nephrogenic diabetes insipidus (DI).<\/jats:p>","DOI":"10.1177\/000992289103001104","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"634-640","source":"Crossref","is-referenced-by-count":21,"title":["Polyuria in Childhood"],"prefix":"10.1177","volume":"30","author":[{"given":"Alexander K.C.","family":"Leung","sequence":"first","affiliation":[{"name":"Alberta Children's Hospital, 1820 Richmond Road SW, Calgary, Alberta, Canada T2T 5C"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wm. Lane M.","family":"Robson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, the University of Calgary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell L.","family":"Halperin","sequence":"additional","affiliation":[{"name":"Department of Medicine, the University of Toronto"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,11,1]]},"reference":[{"key":"atypb1","unstructured":"Libber SM, Plotnick LP Polyuria. In: Hoekelman RA, Blatman S, Nelson NM, (eds.) Primary Pediatric Care. St. Louis: The C.V. Mosby Co., 1987, 1056-9."},{"key":"atypb2","first-page":"2971","volume":"15","author":"Magner PO","year":"1987","journal-title":"Medicine"},{"key":"atypb3","unstructured":"Teitelbaum I., Berl T., Kleeman CR The physiology of the renal concentrating and diluting mechanisms . In: Maxwell MH, Kleeman CR, Narins RG,(eds.) Clinical Disorders of Fluid and Electrolyte Metabolism. New York: McGraw Hill Book Corp., 1987, 79-103."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/014107688808100221"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6646.455"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6655.1047-b"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1542\/peds.86.6.1004","volume":"86","author":"Robson WL","year":"1990","journal-title":"Pediatrics"},{"key":"atypb8","unstructured":"Soffer O., Tuttle EP, Jr. Polyuria. In: Hurst JW, (ed.) Medicine for the Practicing Physician. Boston : Butterworths, 1988, 1103-6."},{"key":"atypb9","unstructured":"Bernard DB, Idelson BA Polyuria. In: Noble J, (ed.) Textbook of General Medicine and Primary Care. Boston: Little, Brown and Co., 1987, 1843-5."},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.39.020188.002233"},{"key":"atypb11","unstructured":"Milner LS, Kaplan BS Polyuria in infants and children. In: Moss AJ, (ed.) Pediatrics Update. New York : Elsevier, 1986, 215-39."},{"key":"atypb12","unstructured":"Villee D. Posterior pituitary disorders. In: Avery ME , First LR, (eds.) Pediatric Medicine. Baltimore: Williams & Wilkins, 1989, 819-25."}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289103001104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289103001104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:24:01Z","timestamp":1777393441000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992289103001104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1991,11]]}},"alternative-id":["10.1177\/000992289103001104"],"URL":"https:\/\/doi.org\/10.1177\/000992289103001104","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11]]}}}