{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:55:40Z","timestamp":1777524940409,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1992,4,1]],"date-time":"1992-04-01T00:00:00Z","timestamp":702086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:p>Precise quantity of fever was determined in 191 cases of childhood bacterial meningitis by calculating the areas between the line indicating 37.8\u00b0C or 39.5\u00b0C temperature and the line connecting all individual temperature values. Temperature measurements were performed rectally one to four times a day throughout the hospitalization. The obtained areas under the curves (AUC), expressed as degree-hours, proved to be a sensitive index for delineating each individual fever pattern and reflected the magnitude of fever more precisely than the traditional fever curves. Children under five had significantly (p &lt;0.05) greater AUC than those at five to 15 years; similarly, patients with Haemophilus influenzae meningitis showed greater AUC (i.e., had more fever) than those with meningococcal disease ( p &lt;0.05). The overall rates of secondary (14%), persistent (16%), and prolonged fever (8%) were virtually identical to previous reports; no drug fever was reported in this study. In cases with prolonged fever, a significantly higher rate (40%) of neurological complications was found compared to those who became afebrile earlier. This method is potentially utilizable in other diseases and conditions where precise measurement of fever is of clinical or scientific relevance.<\/jats:p>","DOI":"10.1177\/000992289203100406","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"221-227","source":"Crossref","is-referenced-by-count":5,"title":["Precise Quantification of Fever in Childhood Bacterial Meningitis"],"prefix":"10.1177","volume":"31","author":[{"given":"Marja","family":"Anttila","sequence":"first","affiliation":[{"name":"Children's Hospital, University of Helsinki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaakko-Juhani","family":"Himberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology University of Helsinki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Peltola","sequence":"additional","affiliation":[{"name":"National Public Health Institute, Mannerheimintie 166, SF-00300, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(70)80077-4"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1973.5.issue-1.05"},{"key":"atypb3","first-page":"192","volume":"20","author":"Rutman DL","year":"1981","journal-title":"ClinPediatr."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198407000-00009"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1007\/BF01995859"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92685-8"},{"key":"atypb7","volume-title":"Clinical Pharmacokinetics: Concepts and Applications","author":"Rowland M.","year":"1989","edition":"2"},{"key":"atypb8","unstructured":"Johnson JE III. Drug fever. In: Murray HW, ed. FUO: Fever of Undetermined Origin. Mount Kisco, NY Futura Publishing Company; 1983 :67-86."},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198103000-00005"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289203100406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289203100406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:24:42Z","timestamp":1777393482000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992289203100406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,4]]}},"alternative-id":["10.1177\/000992289203100406"],"URL":"https:\/\/doi.org\/10.1177\/000992289203100406","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4]]}}}