{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:20:04Z","timestamp":1792192804402,"version":"4.4.0"},"reference-count":8,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[1992,7,1]],"date-time":"1992-07-01T00:00:00Z","timestamp":709948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:p>The effectiveness of CaEDTA alone vs CaEDTA plus BAL was compared retrospectively in a group of 72 children with lead levels between 2.41 \u03bcmol\/L (50 \u03bcg\/dL) and 2.90 \u03bcmol\/L (60 \u03bcg\/dL). The children who received both drugs had higher median zinc protoporphyrin (ZnP) concentrations at the initiation of therapy than children who received CaEDTA alone (160 \u03bcg\/dL vs 96 \u03bcg\/dL, p &lt;.01). There was a significantly increased incidence of vomiting and abnormal liver-function test results in the children who received both drugs. The children who received CaEDTA alone had a greater percent mean fall in lead level at one to three weeks postchelation (30.5 % vs 18.1 %, p &lt;.05). Children who received both CaEDTA and BAL had a greater percent decrease in ZnP at four to eight months postchelation, but there was no difference in percent decrease in lead levels. Children who received both drugs also had a greater number of repeat courses of chelation by six months. The addition of BAL to CaEDTA for treatment of children with lead levels of 2.41 \u03bcmol\/L (50 \u03bcg\/dL) to 2.90 \u03bcmol\/L (60 \u03bcg\/dL) produced greater toxicity and does not seem to prevent repeat chelations within six months.<\/jats:p>","DOI":"10.1177\/000992289203100701","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"386-390","source":"Crossref","is-referenced-by-count":11,"title":["CaEDTA vs CaEDTA Plus BAL to Treat Children with Elevated Blood Lead Levels"],"prefix":"10.1177","volume":"31","author":[{"given":"Mary E.","family":"O'Connor","sequence":"first","affiliation":[{"name":"Division of General Academic Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University, Cleveland, 0H 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1992,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80414-X"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(68)80036-8"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-0847-5"},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1542\/peds.87.2.219","volume":"87","author":"Bellinger D.","year":"1991","journal-title":"Pediatrics"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199001113220203"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1542\/peds.51.2.254","volume":"51","author":"Piomelli S.","year":"1973","journal-title":"Pediatrics"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(71)90121-9"},{"key":"atypb8","first-page":"804","volume":"243","author":"Cory-Slechta DA","year":"1987","journal-title":"Therapeutics"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289203100701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289203100701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:24:50Z","timestamp":1777393490000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992289203100701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7]]},"references-count":8,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1992,7]]}},"alternative-id":["10.1177\/000992289203100701"],"URL":"https:\/\/doi.org\/10.1177\/000992289203100701","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7]]}}}