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With the resurgence of serious complications from streptococcal infection, successful bacteriologic eradication has regained importance. In communities with a high incidence of penicillin failures, alternative antimicrobials should be considered. Cephalosporins, amoxicillin\/clavulanate, and the extended-spectrum macrolides represent logical options under such clinical circumstances.<\/jats:p>","DOI":"10.1177\/000992289203101101","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"642-649","source":"Crossref","is-referenced-by-count":18,"title":["Explanations and Therapies for Penicillin Failure in Streptococcal Pharyngitis"],"prefix":"10.1177","volume":"31","author":[{"given":"Michael E.","family":"Pichichero","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 (716)275-5944"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,11,1]]},"reference":[{"key":"atypb1","unstructured":"Bisno AL Streptococcus pyogenes. In: Mandell GL, ed. 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