{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:14:19Z","timestamp":1782440059301,"version":"3.54.5"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1994,6,1]],"date-time":"1994-06-01T00:00:00Z","timestamp":770428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:p>\n                    Six hundred sixty-three children aged 1 to 16 years with thrombocytosis (defined as a platelet count of more than 500 X 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L) seen in a university hospital over a 1-year period were studied prospectively for etiology. The causes of thrombocytosis were infection (30.6%), hemolytic anemia(19.3%), tissue damage (15.2%), rebound thrombocytosis (14.8%), chronic inflammation (4.1 %), renal disorders (4.1 %), and malignancy (2%). Thrombocytosis associated with multiple, simultaneous causative factors was seen in 3.3% of cases. Among all patients with infections, osteomyelitis and septic arthritis were associated with higher platelet counts than other infections ( P&lt;. 0001). Thrombocytosis secondary to infections was significantly more common in children under 5 years of age, whereas chronic inflammation, malignancy, and renal disorders were more common causes of thrombocytosis in children over 5 years of age. Thrombocytosis of 1 million or more platelets was seen in 13 (2%) children. No thrombocytosis-related complications were seen in any children, and none required any specific treatment. Thrombocytosis is a frequent finding in children. It is due to a variety of etiologic factors and is of little clinical discriminatory value. It is often due to an acute-phase phenomenon in response to infection, tissue damage, blood loss, or anemia, and is rarely due to malignancy.\n                  <\/jats:p>","DOI":"10.1177\/000992289403300605","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"340-343","source":"Crossref","is-referenced-by-count":46,"title":["Thrombocytosis"],"prefix":"10.1177","volume":"33","author":[{"given":"Mulakkan D.","family":"Yohannan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, King Saud University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal E.","family":"Higgy","sequence":"additional","affiliation":[{"name":"Department of Hematology, King Saud University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihab A.","family":"Al-Mashhadani","sequence":"additional","affiliation":[{"name":"Department of Hematology, King Saud University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheruppolil R.","family":"Santhosh-Kumar","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Khalid University Hospital, College of Medicine, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1994,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1542\/peds.84.6.1064","volume":"84","author":"Chan KW","year":"1989","journal-title":"Pediatrics"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80141-6"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80345-8"},{"key":"atypb4","unstructured":"Lee GR, Bithell TC, Foerster J, et al, eds. Wintrobe's Clinical Hematolog. 9th ed. Philadelphia, PA: Lea & Febinger ; 1993 ;1390-1396."},{"key":"atypb5","first-page":"751","volume":"51","author":"Samuel SP","year":"1984","journal-title":"J Pediatr."},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1159\/000208784"},{"key":"atypb7","unstructured":"Lee GR, Bithell TC, Foerster J, et al, eds. Wintrobe's Clinical Hematology. 9th ed. Philadelphia, PA: Lea & Febinger 1993;511."},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114559"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.5.1545.1545"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.5.545"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-68-5-1013"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198411293112205"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.12.2493.2493"},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1203\/00006450-199307000-00014","volume":"34","author":"Cairo MS","year":"1993","journal-title":"Pediatr Res."},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.6.676"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1042\/cs0570129"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1966.tb00125.x"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289403300605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289403300605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:22:35Z","timestamp":1777393355000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992289403300605"}},"subtitle":["Etiologic Analysis of 663 Patients"],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,6]]}},"alternative-id":["10.1177\/000992289403300605"],"URL":"https:\/\/doi.org\/10.1177\/000992289403300605","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,6]]}}}