{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:24:31Z","timestamp":1787239471067,"version":"build-2736575974"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1996,2,1]],"date-time":"1996-02-01T00:00:00Z","timestamp":823132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p>The purpose of this study was to assess the long-term effects of pneumococcal meningitis in children. From 1967 to 1988, a total of 90 children were admitted to the Hospital for Infectious Diseases, Thessaloniki, Greece, with the diagnosis of pneumococcal meningitis. Sixteen patients died in the hospital as a direct result of meningitis. Eleven others were excluded from the study (neurologic deficits prior to onset of meningitis, two; death subsequent to hospitalization, two; recurrent meningitis, seven). Of the remaining 63 survivors, we were able to evaluate 47 patients (75%). Evaluation was performed 4 to 23 years (mean 12.3 \u00b1 5.8 years) after discharge. Forty patients returned to hospital for evaluation, and seven were evaluated by their primary physicians, who sent information by a standardized questionnaire. The following examinations were carried out: history, physical and neurologic examination, ophthalmologic and hearing evaluation, and psychometric testing. Fourteen patients (30%) had at least one neurologic handicap; nine (19%) had mental retardation, eight (17%) hearing loss, seven (15%) seizure disorder, five (11%) motor defects, and one each (2%) behavioral problems and visual impairment. The presence of coma was the strongest predictor of increased morbidity. The high frequency of long-term sequelae observed in our study supports the need of an effective vaccine.<\/jats:p>","DOI":"10.1177\/000992289603500204","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"72-78","source":"Crossref","is-referenced-by-count":53,"title":["Long-Term Sequelae of Pneumococcal Meningitis in Children"],"prefix":"10.1177","volume":"35","author":[{"given":"Andreas","family":"Pikis","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Hospital for Infectious Diseases, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kavaliotis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital for Infectious Diseases, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Tsikoulas","sequence":"additional","affiliation":[{"name":"First Pediatric Department, University of Thessaloniki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayiotis","family":"Andrianopoulos","sequence":"additional","affiliation":[{"name":"Kentrikon Hospital, Thessaloniki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Venzon","sequence":"additional","affiliation":[{"name":"Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotiris","family":"Manios","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital for Infectious Diseases, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1996,2,1]]},"reference":[{"key":"atypb1","unstructured":"Feigin RD Bacterial meningitis beyond the neonatal period. 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