{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:47:35Z","timestamp":1777524455963,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[1996,12,1]],"date-time":"1996-12-01T00:00:00Z","timestamp":849398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1996,12]]},"abstract":"<jats:p>The objective of the study was to define the longitudinal evolution of cardiac rhabdomyomas (CR) in patients with tuberous sclerosis complex (TSC). A cohort of patients with TSC who had undergone videotaped echocardiographic (ECHO) examination during the 10-year interval (1984-1994) were retrospectively studied by reviewing and quantifying the CR appearance and associated cardiac abnormalities in sequentially obtained ECHO examinations. Sixteen patients with TSC (8 males) underwent a total of 35 recorded studies. Ten of the 16 (62.5%) had CR identified at initial study; none were found in the atria. Localization was the ventricular walls as compared with the ventricular septum by a ratio of 2:1. The number of CRs sequentially studied declined as follows; initial study: 23 lesions in 10 patients; second study: 16 lesions in 8 patients; third study: 12 lesions in 5 patients; and fourth study: 4 lesions in 2 patients. Total CR size index declined at each study as follows: initial index of 2,684; second index of 1,746 (-35% from initial); third index 1,141 (-57% from initial); and fourth index 705 (-74% from initial). Complete spontaneous regression of CR was seen by age 6 years with prolonged gradual resolution thereafter. Two patients had bicuspid aortic valves and two had conduction defects. Patients with TSC who have CR can be expected to experience a decline in both the number and size of CR over time; early complete regression on ECHO occurs before age 6 years.<\/jats:p>","DOI":"10.1177\/000992289603501202","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:21:41Z","timestamp":1182460901000},"page":"615-619","source":"Crossref","is-referenced-by-count":43,"title":["Evolution of Cardiac Rhabdomyoma in Tuberous Sclerosis Complex"],"prefix":"10.1177","volume":"35","author":[{"suffix":"Jr.","given":"Francis J.","family":"Dimario","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology at the University of Connecticut Health Center, Farmington, CT; Connecticut Children's Medical Center, Department of Pediatrics, Division of Pediatric Neurology, 282 Washington Avenue, Hartford, CT 06106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Diana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harris","family":"Leopold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Chameides","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, at Hartford Hospital, Hartford, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690030080013"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1376"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90618-Z"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.2.196"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.3.367"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050110"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(85)90508-9"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370402"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(77)80099-3"},{"key":"atypb10","first-page":"147","volume-title":"Tuberous Sclerosis","author":"Mair DD","year":"1988","edition":"2"},{"key":"atypb11","first-page":"34","volume":"102","author":"Oster AG","year":"1978","journal-title":"Arch Pathol Lab Med"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(86)90067-6"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.8.1223"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1993.02160300075027"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)91109-J"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.4_Spec_No.377"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1177\/088307389200700219"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90079-2"},{"key":"atypb19","first-page":"265","volume":"13","author":"Muhler E","year":"1992","journal-title":"Pediatr Cardiol"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1177\/000992288702601008"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198507010-00030"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80998-2"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80432-2"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90150-D"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289603501202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289603501202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:23:30Z","timestamp":1777393410000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992289603501202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1996,12]]}},"alternative-id":["10.1177\/000992289603501202"],"URL":"https:\/\/doi.org\/10.1177\/000992289603501202","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,12]]}}}