{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:55:28Z","timestamp":1777524928642,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1998,2,1]],"date-time":"1998-02-01T00:00:00Z","timestamp":886291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1998,2]]},"abstract":"<jats:p>Racial differences in insulin secretion and insulin sensitivity in healthy children were studied by administering a 2-hour hyperglycemic clamp (225 mg\/dL) to 14 black and 16 white healthy adolescents (Tanner II-V), and 12 black and 11 white prepubertal children, matched for age, body mass index, and Tanner I pubertal development. In prepubertal children, fasting and first-phase insulin concentrations were higher in blacks compared with whites (14.7 \u00b11.3 vs 10.4 \u00b11.2, P=0.02, and 76.9 \u00b16.8 vs 52.1 \u00b16.4 \u03bcu\/mL, P=0.016). There were no differences in second- phase insulin levels and insulin sensitivity index. In pubertal adolescents, first-phase and second- phase insulin concentrations were higher in blacks compared with whites (first-phase: 157.3 \u00b118.3 vs 77.0 \u00b18.7 \u03bcu\/mL, P=0.0003; second-phase: 175.0 \u00b124.3 vs 108.7 \u00b18.8 \u03bcu\/mL, P=0.012). Insulin sensitivity index was 35% lower in black adolescents compared with whites (P=0.02). These findings indicate that significant differences in insulin secretion and sensitivity are detectable early in childhood in healthy African-American vs American whites. However, genetic (race) vs environ mental factors (physical activity\/fitness, energy balance) should be carefully scrutinized as potential factors responsible for such differences. Clin Pediatr. 1998;37:81-88<\/jats:p>","DOI":"10.1177\/000992289803700204","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:50:16Z","timestamp":1196099416000},"page":"81-88","source":"Crossref","is-referenced-by-count":53,"title":["Insulin Secretion and Sensitivity in Healthy African-American vs American White Children"],"prefix":"10.1177","volume":"37","author":[{"given":"Silva","family":"Arslanian","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital, University of Pittsburgh, School of Medicine, Pittsburgh, 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