{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:56:01Z","timestamp":1777524961185,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p>The authors evaluated clinical and epidemiologic features of neurofibromatosis type 1 (NF-1) as predictive factors of severity of the disease. The data were retrieved from medical records of 110 children with NF-1 followed up during the period 1974-1991 (mean duration of follow-up 6.7 years). Presence of macrocephaly correlated with higher grade of severity of the disease (P10.018). Familial NF-1 was more common in patients with grade 4 disease than in children with grade 1 severity (P&lt;0.05; odds ratio 2.9, confidence limits 0.85-10.5). The specificity of positive family history and macrocephaly as predictive factors for the grade 4 disease was 90% and 89%, respectively, and sensitivity was 71% and 36%, correspondingly. Positive predictive value of familial NF-1 and macrocephaly was 24% and 31%, respectively. In conclusion, although patients with family history of NF-1 and with macrocephaly tend to have more severe disease, the clinical utility of these features as predictive factors for severity is limited.<\/jats:p>","DOI":"10.1177\/000992289803700503","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:21:41Z","timestamp":1182460901000},"page":"295-299","source":"Crossref","is-referenced-by-count":9,"title":["Neurofibromatosis Type 1 in Childhood: Evaluation of Clinical and Epidemiologic Features as Predictive Factors for Severity"],"prefix":"10.1177","volume":"37","author":[{"given":"A.","family":"Zvulunov","sequence":"first","affiliation":[{"name":"Dermatology Units, Schneider's Children Medical Center, Petah-Tiqva, Israel; Department of Dermatology, Soroka Medical Center, Beer-Sheva, 84101, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Weitz","sequence":"additional","affiliation":[{"name":"Neurology Units, Schneider's Children Medical Center, Petah-Tiqva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Metzker","sequence":"additional","affiliation":[{"name":"Dermatology Units, Schneider's Children Medical Center, Petah-Tiqva, Israel; Department of Dermatology, Surasky Medical Center, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80137-4"},{"key":"atypb2","first-page":"173","volume":"9","author":"Pascual-Castroviejo I","year":"1994","journal-title":"Neurologia"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00303606"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(94)70122-9"},{"key":"atypb5","unstructured":"5. National Institutes of Health. Neurofibromatosis. National Institutes Consensus Development Conference Statement. Bethesda, MD: The Institute, 1987:6-6."},{"key":"atypb6","unstructured":"6. Riccardi VM. In: Riccardi VM, ed. Neurofibromatosis: Phenotype, Natural History and Pathogenesis, 2nd ed. Baltimore: The Johns Hopkins University Press; 1992:165-176, 213-214, 359-387."},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.11.704"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.41.1.106"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.3.170"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.431"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690200040007"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690200082015"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289803700503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289803700503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:24:46Z","timestamp":1777393486000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992289803700503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1177\/000992289803700503"],"URL":"https:\/\/doi.org\/10.1177\/000992289803700503","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}