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The more pubertally advanced sister by magnetic resonance imaging had an optic pathway glioma while none was present in her twin sister. Precocious puberty is not an unexpected complication of neurofibromatosis type 1 and is always associated with the presence of an optic pathway glioma. These sisters emphasize the striking similarity that is expected of monozygotic twins and the need for investigation when intertwin differences in growth and\/or development arise.<\/jats:p>","DOI":"10.1177\/000992289803700504","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:21:41Z","timestamp":1182460901000},"page":"301-304","source":"Crossref","is-referenced-by-count":8,"title":["Discordant Puberty in Monozygotic Twin Sisters with Neurofibromatosis Type 1 (NFl)"],"prefix":"10.1177","volume":"37","author":[{"given":"Thaddeus E.","family":"Kelly","sequence":"first","affiliation":[{"name":"Division of Medical Genetics, University of Virginia School of Medicine, Charlottesville and Staunton, Virginia; Division of Medical Genetics, Box 386, Health Sciences Center, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George T.","family":"Sproul","sequence":"additional","affiliation":[{"name":"Division of Blue Ridge Pediatrics, University of Virginia School of Medicine, Charlottesville and Staunton, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milagros G.","family":"Huerta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Rogol","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, University of Virginia School of Medicine, Charlottesville and Staunton, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1998,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1017\/S0001566000006929"},{"key":"atypb2","first-page":"137","volume":"47","author":"Treloar SA","year":"1990","journal-title":"Am J Hum Genet"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320390207"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1017\/S0001566000002300"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1017\/S0001566000003305"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(94)70122-9"},{"key":"atypb7","first-page":"305","volume":"53","author":"Easton DF","year":"1993","journal-title":"Am J Hum Genet"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1985.02140130035025"},{"key":"atypb9","first-page":"806","volume":"81","author":"Angeletti G","year":"1990","journal-title":"Recent Progr Med"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70449-3"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70327-5"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(88)80041-X"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320410217"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289803700504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992289803700504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:24:46Z","timestamp":1777393486000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992289803700504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1177\/000992289803700504"],"URL":"https:\/\/doi.org\/10.1177\/000992289803700504","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}