{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:10:21Z","timestamp":1777680621313,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hosp Pharm"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Background: The monitoring of hypertension treatment can provide insight into the rational drug use pattern. The objective of this study was to examine the antihypertensive medication use among South Indian adults with hypertension in compliance with the hypertension treatment guidelines (Seventh Joint National Committee [JNC 7] and JNC 8). Methods and Results: A total of 550 hypertensive people aged &gt;25 years were included in this retrospective cross-sectional study. The order of drugs prescribed in the year 2012 was beta blockers (BB) &gt; calcium channel blockers (CCB) &gt; CCB + BB &gt; angiotensin receptor blockers (ARB) &gt; angiotensin-converting enzyme inhibitors (ACEI) &gt; thiazide diuretics, whereas in the year 2014, the order has changed drastically, namely, ACEI &gt; CCB &gt; ARB &gt; BB &gt; thiazide diuretics ( P &lt; .001). Most notably, there was a large increase in the use of monotherapy (from 56.9% to 82.5%, P &lt; .001). The usage of BB has simply moved from the first position to the last position in concordance with JNC 8 guidelines, whereas use of thiazide diuretics was found to be the least preferred drug in the 2012 prescriptions, thus deviating from JNC 7 guidelines. The use of generic names (28.3% vs 11.3%) and National List of Essential Medicines (NLEM) compliance (79.3% vs 60.9%) were significantly more in the calendar year 2012 than in the calendar year 2014 ( P &lt; .001). Conclusions: Antihypertensive medication use has gone through wide variations among south Indian adults with hypertension. Combination therapy regimens must be adopted as per the guidelines for achievement of blood pressure goals.<\/jats:p>","DOI":"10.1177\/0018578717738080","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T05:47:53Z","timestamp":1509515273000},"page":"107-112","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Antihypertensive Prescription Pattern and Compliance to JNC 7 and JNC 8 at Tertiary Care Government Hospital, Hyderabad, India: A Cross-sectional Retrospective Study"],"prefix":"10.1177","volume":"53","author":[{"given":"Varsha","family":"Varakantham","sequence":"first","affiliation":[{"name":"National Institute of Nutrition, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok Kumar","family":"Kurakula Sailoo","sequence":"additional","affiliation":[{"name":"Gandhi Hospital, Secunderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh Kumar","family":"Bharatraj","sequence":"additional","affiliation":[{"name":"National Institute of Nutrition, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11,1]]},"reference":[{"key":"bibr1-0018578717738080","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000146"},{"key":"bibr2-0018578717738080","doi-asserted-by":"crossref","unstructured":"Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7). Hypertension. 2003;42:1206-1252. https:\/\/www.nhlbi.nih.gov\/files\/docs\/guidelines\/jnc7full.pdf. Accessed August 22, 2017.","DOI":"10.1161\/01.HYP.0000107251.49515.c2"},{"key":"bibr3-0018578717738080","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"bibr4-0018578717738080","unstructured":"Government of India, Ministry of Health & Family Welfare. National List of Essential Medicines. Published 2011. http:\/\/pharmaceuticals.gov.in\/pdf\/NLEM.pdf. Accessed on August 23, 2017."},{"key":"bibr5-0018578717738080","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1521"},{"key":"bibr6-0018578717738080","unstructured":"Shalini Agarwal S, Joshi MC, Kapoor AK. An analysis of prescription patterns in cases of uncomplicated hypertension in a tertiary care hospital. Natl J Integr Res Med. 2012;3(1):13-20. http:\/\/search.ebscohost.com\/login.aspx?direct=true&db=a9h&AN=71533650&site=ehost-live. Accessed on August 21, 2017."},{"key":"bibr7-0018578717738080","unstructured":"Kuchake VG, Maheshwari OD, Surana SJ, Patil PH, Dighore PN. Prescription pattern of antihypertensive drugs in uncomplicated hypertensive patients at teaching hospital. Indian J Pharm Pract. 2009;2(2):74-80. http:\/\/www.ijopp.org\/sites\/default\/files\/IJOPP_v2_i2_2009_12.pdf. Accessed on August 21, 2017."},{"issue":"3","key":"bibr8-0018578717738080","first-page":"72","volume":"6","author":"Ushadevi KH","year":"2013","journal-title":"Asian J Pharm Clin Res"},{"key":"bibr9-0018578717738080","first-page":"456","volume":"33","author":"Xavier D","year":"2001","journal-title":"Indian J Pharmacol"},{"key":"bibr10-0018578717738080","unstructured":"Pai PG, Shenoy J, Sanji N. Prescribing patterns of antihypertensive drugs in a tertiary care hospital. Drug Invent Today. 2011;3(4):38-40. www.saspublisher.com."},{"key":"bibr11-0018578717738080","doi-asserted-by":"publisher","DOI":"10.5455\/2319-2003.ijbcp20140409"},{"key":"bibr12-0018578717738080","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2009.109"},{"key":"bibr13-0018578717738080","unstructured":"Li L, Liu D, Xie X, Dong P, Lin Y. Prescription patterns of antihypertensive medicines in China: a descriptive analysis in real-world conditions. In: Drummond M, Mullins CD, eds. Value in Health. Boston, MA: Elsevier; 2017:A1-A383. https:\/\/www.ispor.org\/ScientificPresentationsDatabase\/Presentation\/71227. Accessed September 28, 2017."},{"key":"bibr14-0018578717738080","doi-asserted-by":"publisher","DOI":"10.5455\/ijmsph.2014.170420146"},{"key":"bibr15-0018578717738080","unstructured":"Sultana S, Hamid K, Islam KMS, et al. Assessment of prescription pattern of hypertensive patient\u2019s prescription: a prescription survey study from various hospitals of Bangladesh. Eur J Sci Res. 2010;40(4):500-505. https:\/\/www.researchgate.net\/profile\/Abu_Hasanat_Md_Zulfiker\/publication\/235999063_Assessment_of_Prescription_Pattern_of_Hypertensive_Patient%27s_Prescription_A_Prescription_Survey_Study_from_Various_Hospitals_of_Bangladesh\/links\/00b7d5156bcfc24bb9000000\/Assessment-of-Prescription-Pattern-of-Hypertensive-Patients-Prescription-A-Prescription-Survey-Study-from-Various-Hospitals-of-Bangladesh.pdf. 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