{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:18:39Z","timestamp":1777681119017,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T00:00:00Z","timestamp":1575676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hosp Pharm"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>Purpose\/Background: Percutaneous left ventricular assist devices (pVADs) require a continuous purge solution containing heparin to prevent pump thrombosis and device failure. Data regarding alternative options in patients who have suspected heparin-induced thrombocytopenia (HIT) are limited. Methods: In this report, we describe a 68-year-old white man with cardiogenic shock with an Impella CP device managed with a low concentration argatroban-based purge solution secondary to a suspected diagnosis of HIT. Results: The purge solution was initiated as argatroban in dextrose 10% at a concentration of 0.12 mg\/mL and was subsequently decreased twice to 0.06 and 0.015 mg\/mL based on the patient\u2019s clinical course. Conclusions: This case report describes the safe and effective use of argatroban purge solution necessary for anticoagulation although further studies are needed to confirm these findings.<\/jats:p>","DOI":"10.1177\/0018578719888905","type":"journal-article","created":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T05:25:00Z","timestamp":1575696300000},"page":"241-246","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic Anticoagulation With an Ultra-Low Concentration Argatroban-Based Purge Solution for Percutaneous Ventricular Assist Device in Patient With Heparin-Induced Thrombocytopenia"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2020-0571","authenticated-orcid":false,"given":"Andrea Sikora","family":"Newsome","sequence":"first","affiliation":[{"name":"The University of Georgia College of Pharmacy, Augusta, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Taylor","sequence":"additional","affiliation":[{"name":"The University of Georgia College of Pharmacy, Augusta, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth","family":"Garner","sequence":"additional","affiliation":[{"name":"The University of Georgia College of Pharmacy, Augusta, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,7]]},"reference":[{"key":"bibr1-0018578719888905","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.260"},{"key":"bibr2-0018578719888905","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-011-3434-7"},{"key":"bibr3-0018578719888905","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.613596"},{"key":"bibr4-0018578719888905","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1995"},{"key":"bibr5-0018578719888905","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.065"},{"key":"bibr6-0018578719888905","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2018.02.002"},{"key":"bibr7-0018578719888905","volume-title":"Impella Ventricular Support Systems for Use During Cardiogenic Shock and High-Risk PCI","author":"Abiomed I","year":"2016"},{"key":"bibr8-0018578719888905","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.036"},{"key":"bibr9-0018578719888905","doi-asserted-by":"publisher","DOI":"10.1177\/0897190017727191"},{"key":"bibr10-0018578719888905","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp160212"},{"key":"bibr11-0018578719888905","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018024489"},{"key":"bibr12-0018578719888905","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S38762"}],"container-title":["Hospital Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0018578719888905","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0018578719888905","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0018578719888905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:39:01Z","timestamp":1777451941000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0018578719888905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,7]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1177\/0018578719888905"],"URL":"https:\/\/doi.org\/10.1177\/0018578719888905","relation":{},"ISSN":["0018-5787","1945-1253"],"issn-type":[{"value":"0018-5787","type":"print"},{"value":"1945-1253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,7]]}}}